Phenotypes associated with this allele

• Allele Symbol: Lpcat3^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433127
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lpcat3^tm1a(EUCOMM)Wtsi/Lpcat3^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5822845

Genotype
MGI:5822845

hm1

• Allelic Composition: Lpcat3^{tm1a(EUCOMM)Wtsi}/Lpcat3^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0455_5_A07

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:220827 )

• although mice are born at the expected Mendelian ratio, no mice survive beyond P2

• postnatal survival can be extended by subcutaneous glucose injections; however, pups fail to thrive and invariably die by P6

homeostasis/metabolism

decreased circulating glucose level ( J:220827 )

• blood glucose levels are very low at birth

abnormal lipid metabolism ( J:220827 )

• analysis of gene expression in the liver and small intestine of newborn pups revealed changes in several genes linked to lipid metabolism