Phenotypes associated with this allele

• Allele Symbol: Rad18^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433190
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad18^tm1a(EUCOMM)Wtsi/Rad18^tm1a(EUCOMM)Wtsi	B6Brd;B6Dnk;B6N-Tyr^c-Brd Rad18^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6272823
hm2	Rad18^tm1a(EUCOMM)Wtsi/Rad18^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Rad18^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781715
hm3	Rad18^tm1a(EUCOMM)Wtsi/Rad18^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5791060

Genotype
MGI:6272823

hm1

• Allelic Composition: Rad18^{tm1a(EUCOMM)Wtsi}/Rad18^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Rad18^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0027_4_B02

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal arrector pilli muscle morphology ( J:232539 )

♀ • at necropsy (16 weeks of age), mice fed a high-fat diet exhibit normal skin but unusually prominent arrector pili muscles

muscle

abnormal arrector pilli muscle morphology ( J:232539 )

♀ • at necropsy (16 weeks of age), mice fed a high-fat diet exhibit normal skin but unusually prominent arrector pili muscles

Genotype
MGI:5781715

hm2

• Allelic Composition: Rad18^{tm1a(EUCOMM)Wtsi}/Rad18^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Rad18^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0027_4_B02

Data Sources

IMPC Data for Rad18

behavior/neurological

decreased locomotor activity ( J:175295 )

IMPC - WTSI

growth/size/body

decreased body weight ( J:165965 , J:175295 )

IMPC - WTSI (J:165965)

IMPC - WTSI (J:175295)

hematopoietic system

increased hematocrit ( J:165965 )

IMPC - WTSI

increased mean corpuscular hemoglobin concentration ( J:175295 )

IMPC - WTSI

increased mean corpuscular volume ( J:165965 )

IMPC - WTSI

integument

abnormal coat/ hair morphology ( J:175295 )

♂

IMPC - WTSI

abnormal hair texture ( J:175295 )

♀

IMPC - WTSI

adipose tissue

decreased total body fat amount ( J:165965 )

♂

IMPC - WTSI

Genotype
MGI:5791060

hm3

• Allelic Composition: Rad18^{tm1a(EUCOMM)Wtsi}/Rad18^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0027_4_B02

behavior/neurological

hyperactivity ( J:213427 )

liver/biliary system

abnormal liver physiology ( J:213427 )

• absent or minimal hepatic lipidosis

cellular

chromosomal instability ( J:213427 )

growth/size/body

decreased body weight ( J:213427 )

homeostasis/metabolism

increased energy expenditure ( J:213427 )

increased carbon dioxide production ( J:213427 )

increased oxygen consumption ( J:213427 )