Phenotypes associated with this allele

• Allele Symbol: Pfn1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433191
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pfn1^tm1a(EUCOMM)Wtsi/Pfn1^tm1a(EUCOMM)Wtsi	B6Brd;B6Dnk;B6N-Tyr^c-Brd Pfn1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5700958
ht2	Pfn1^tm1a(EUCOMM)Wtsi/Pfn1^+	B6Brd;B6Dnk;B6N-Tyr^c-Brd Pfn1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5706060

Genotype
MGI:5700958

hm1

• Allelic Composition: Pfn1^{tm1a(EUCOMM)Wtsi}/Pfn1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Pfn1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0046_1_C10

Data Sources

IMPC Data for Pfn1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

Genotype
MGI:5706060

ht2

• Allelic Composition: Pfn1^{tm1a(EUCOMM)Wtsi}/Pfn1⁺
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Pfn1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0046_1_C10

Data Sources

IMPC Data for Pfn1

adipose tissue

decreased total body fat amount ( J:175295 )

♀

IMPC - WTSI

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

decreased circulating fructosamine level ( J:175295 )

♀

IMPC - WTSI

increased circulating magnesium level ( J:211773 )

♀

IMPC - WTSI

increased circulating amylase level ( J:211773 )

♂

IMPC - WTSI

improved glucose tolerance ( J:211773 )

♂

IMPC - WTSI

skeleton

decreased bone mineral content ( J:175295 )

♀

IMPC - WTSI

vision/eye

abnormal cornea morphology ( J:211773 )

♂

IMPC - WTSI

cornea opacity ( J:211773 )

IMPC - WTSI

fused cornea and lens ( J:211773 )

♀

IMPC - WTSI