Phenotypes associated with this allele

• Allele Symbol: Ltbp1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433604
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ltbp1^tm1a(EUCOMM)Wtsi/Ltbp1^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Ltbp1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781661
ht2	Ltbp1^tm1a(EUCOMM)Wtsi/Ltbp1^+	B6JTyr;B6N-Ltbp1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781660

Genotype
MGI:5781661

hm1

• Allelic Composition: Ltbp1^{tm1a(EUCOMM)Wtsi}/Ltbp1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Ltbp1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0127_1_A03

Data Sources

IMPC Data for Ltbp1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

craniofacial

abnormal cranium morphology ( J:175295 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:175295 )

IMPC - WTSI

abnormal incisor morphology ( J:175295 )

♂

IMPC - WTSI

abnormal snout morphology ( J:175295 )

IMPC - WTSI

growth/size/body

abnormal tooth morphology ( J:175295 )

IMPC - WTSI

abnormal incisor morphology ( J:175295 )

♂

IMPC - WTSI

abnormal snout morphology ( J:175295 )

IMPC - WTSI

decreased body weight ( J:175295 )

IMPC - WTSI

decreased body length ( J:175295 )

IMPC - WTSI

hematopoietic system

increased hemoglobin content ( J:175295 )

IMPC - WTSI

increased mean corpuscular hemoglobin ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

increased blood urea nitrogen level ( J:175295 )

IMPC - WTSI

decreased circulating cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating HDL cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating LDL cholesterol level ( J:175295 )

IMPC - WTSI

decreased circulating iron level ( J:175295 )

IMPC - WTSI

decreased circulating alanine transaminase level ( J:175295 )

IMPC - WTSI

decreased circulating aspartate transaminase level ( J:175295 )

IMPC - WTSI

decreased circulating serum albumin level ( J:175295 )

IMPC - WTSI

decreased circulating total protein level ( J:175295 )

IMPC - WTSI

limbs/digits/tail

abnormal radius morphology ( J:175295 )

IMPC - WTSI

abnormal ulna morphology ( J:175295 )

IMPC - WTSI

skeleton

abnormal cranium morphology ( J:175295 )

♂

IMPC - WTSI

abnormal tooth morphology ( J:175295 )

IMPC - WTSI

abnormal incisor morphology ( J:175295 )

♂

IMPC - WTSI

abnormal radius morphology ( J:175295 )

IMPC - WTSI

abnormal ulna morphology ( J:175295 )

IMPC - WTSI

decreased bone mineral content ( J:175295 )

IMPC - WTSI

Genotype
MGI:5781660

ht2

• Allelic Composition: Ltbp1^{tm1a(EUCOMM)Wtsi}/Ltbp1⁺
• Genetic Background: B6JTyr;B6N-Ltbp1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0127_1_A03

Data Sources

IMPC Data for Ltbp1

hematopoietic system

increased leukocyte cell number ( J:175295 )

IMPC - WTSI

immune system

increased leukocyte cell number ( J:175295 )

IMPC - WTSI