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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppip5k2tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4433621
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppip5k2tm1a(EUCOMM)Wtsi/Ppip5k2tm1a(EUCOMM)Wtsi involves: C57BL/6N MGI:6198763
ht2
 		Ppip5k2tm1a(EUCOMM)Wtsi/Ppip5k2+ involves: C57BL/6N MGI:6198764


Genotype
MGI:6198763
hm1
Allelic
Composition		 Ppip5k2tm1a(EUCOMM)Wtsi/Ppip5k2tm1a(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppip5k2tm1a(EUCOMM)Wtsi mutation (1 available); any Ppip5k2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
cochlear outer hair cell degeneration ( J:260825 )
• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls
abnormal auditory brainstem response waveform shape ( J:260825 )
• significant reduction in ABR wave I amplitudes at 24 kHz in older homozygous mice
increased or absent threshold for auditory brainstem response ( J:260825 )
• at P90 the threshold at 32 kHz is significantly increased
• at P120 and P150 the threshold at 24 kHz is significantly increased
impaired hearing ( J:260825 )
• late onset high-frequency progressive hearing loss

nervous system
cochlear outer hair cell degeneration ( J:260825 )
• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
nonsyndromic deafness DOID:0050563 J:260825




Genotype
MGI:6198764
ht2
Allelic
Composition		 Ppip5k2tm1a(EUCOMM)Wtsi/Ppip5k2+
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppip5k2tm1a(EUCOMM)Wtsi mutation (1 available); any Ppip5k2 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
cochlear outer hair cell degeneration ( J:260825 )
• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls
increased or absent threshold for auditory brainstem response ( J:260825 )
• at P150 the threshold at 24 kHz is significantly increased

nervous system
cochlear outer hair cell degeneration ( J:260825 )
• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory