All Phenotypes Ppip5k2<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ppip5k2^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4433621

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ppip5k2^{tm1a(EUCOMM)Wtsi}/Ppip5k2^{tm1a(EUCOMM)Wtsi}	involves: C57BL/6N	MGI:6198763
ht2	Ppip5k2^{tm1a(EUCOMM)Wtsi}/Ppip5k2⁺	involves: C57BL/6N	MGI:6198764

Allelic Composition	Ppip5k2^{tm1a(EUCOMM)Wtsi}/Ppip5k2^{tm1a(EUCOMM)Wtsi}
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppip5k2^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Ppip5k2 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

cochlear outer hair cell degeneration ( J:260825 )

• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls

abnormal auditory brainstem response waveform shape ( J:260825 )

• significant reduction in ABR wave I amplitudes at 24 kHz in older homozygous mice

increased or absent threshold for auditory brainstem response ( J:260825 )

• at P90 the threshold at 32 kHz is significantly increased

• at P120 and P150 the threshold at 24 kHz is significantly increased

impaired hearing ( J:260825 )

• late onset high-frequency progressive hearing loss

nervous system

cochlear outer hair cell degeneration ( J:260825 )

• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
nonsyndromic deafness		DOID:0050563		J:260825

Allelic Composition	Ppip5k2^{tm1a(EUCOMM)Wtsi}/Ppip5k2⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppip5k2^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Ppip5k2 mutation (75 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

cochlear outer hair cell degeneration ( J:260825 )

• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls

increased or absent threshold for auditory brainstem response ( J:260825 )

• at P150 the threshold at 24 kHz is significantly increased

nervous system

cochlear outer hair cell degeneration ( J:260825 )

• at P150 a greater degree of degeneration of OHCs is seen in the basal coil compared to wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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