Phenotypes associated with this allele

• Allele Symbol: Brpf1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433631
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Brpf1^tm1a(EUCOMM)Wtsi/Brpf1^tm1a(EUCOMM)Wtsi	involves: C57BL/6J * C57BL/6N	MGI:5896563
ht2	Brpf1^tm1a(EUCOMM)Wtsi/Brpf1^+	involves: C57BL/6J * C57BL/6N	MGI:5896562
ht3	Brpf1^tm1a(EUCOMM)Wtsi/Brpf1^+	Not Specified	MGI:5450498

Genotype
MGI:5896563

hm1

• Allelic Composition: Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0069_1_G06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:222304 )

• homozygotes appear to die prior to E11.5

Genotype
MGI:5896562

ht2

• Allelic Composition: Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1⁺
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: EPD0069_1_G06

normal phenotype

no abnormal phenotype detected ( J:222304 )

• mice are rather indistinguishable from wild-type controls

Genotype
MGI:5450498

ht3

• Allelic Composition: Brpf1^{tm1a(EUCOMM)Wtsi}/Brpf1⁺
• Genetic Background: Not Specified
• Cell Lines: EPD0069_1_G06

Data Sources

IMPC Data for Brpf1

growth/size/body

decreased body weight ( J:165965 )

IMPC - HAR

skeleton

decreased bone mineral density ( J:165965 )

IMPC - HAR

hematopoietic system

decreased T cell number ( J:165965 )

IMPC - HAR

increased monocyte cell number ( J:165965 )

IMPC - HAR

immune system

decreased T cell number ( J:165965 )

IMPC - HAR

increased monocyte cell number ( J:165965 )

IMPC - HAR