All Phenotypes Nek9<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nek9^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4433670

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nek9^{tm1a(EUCOMM)Wtsi}/Nek9^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Nek9^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5706046
ht2	Nek9^{tm1a(EUCOMM)Wtsi}/Nek9⁺	C57BL/6N-Nek9^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5706045

Allelic Composition	Nek9^{tm1a(EUCOMM)Wtsi}/Nek9^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Nek9^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0419_4_B09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek9^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Nek9 mutation (50 available)

Data Sources

IMPC Data for Nek9

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

embryo

placenta hemorrhage ( J:261316 )

• hemorrhagic areas/blood pools are seen in the E14.5 placenta

abnormal placenta morphology ( J:261316 )

• reduced cellular density at E14.5

abnormal placental labyrinth vasculature morphology ( J:261316 )

• labyrinth vascular defect at E14.5

small placenta ( J:261316 )

• small placenta at E14.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

Allelic Composition	Nek9^{tm1a(EUCOMM)Wtsi}/Nek9⁺
Genetic Background	C57BL/6N-Nek9^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0419_4_B09

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nek9^{tm1a(EUCOMM)Wtsi} mutation (1 available); any Nek9 mutation (50 available)

Data Sources

IMPC Data for Nek9

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating iron level ( J:211773 )

IMPC - WTSI

immune system

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

integument

abnormal skin appearance ( J:211773 )

IMPC - WTSI

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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