Phenotypes associated with this allele

• Allele Symbol: Kdm4b^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433704
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm4b^tm1a(EUCOMM)Wtsi/Kdm4b^tm1a(EUCOMM)Wtsi	B6Dnk;B6Brd;B6N-Tyr^c-Brd Kdm4b^tm1a(EUCOMM)Wtsi/WtsiH	MGI:6262743
ht2	Kdm4b^tm1a(EUCOMM)Wtsi/Kdm4b^+	B6Dnk;B6Brd;B6N-Tyr^c-Brd Kdm4b^tm1a(EUCOMM)Wtsi/WtsiH	MGI:5781649

Genotype
MGI:6262743

hm1

• Allelic Composition: Kdm4b^{tm1a(EUCOMM)Wtsi}/Kdm4b^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Dnk;B6Brd;B6N-Tyr^c-Brd Kdm4b^{tm1a(EUCOMM)Wtsi}/WtsiH
• Cell Lines: EPD0070_4_E10

Data Sources

IMPC Data for Kdm4b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:302280 )

• lethality occurs late during development between E14.5 and weaning age

preweaning lethality, incomplete penetrance ( J:211773 , J:302280 )

IMPC - WTSI (J:211773)

MGI

• only 3% of the expected 25% of mice are obtained at weaning, with all being females (J:302280)

Genotype
MGI:5781649

ht2

• Allelic Composition: Kdm4b^{tm1a(EUCOMM)Wtsi}/Kdm4b⁺
• Genetic Background: B6Dnk;B6Brd;B6N-Tyr^c-Brd Kdm4b^{tm1a(EUCOMM)Wtsi}/WtsiH
• Cell Lines: EPD0070_4_E10

Data Sources

IMPC Data for Kdm4b

behavior/neurological

abnormal behavior ( J:175295 )

IMPC - WTSI

nervous system

abnormal brain size ( J:302280 )

♂ • total brain area is reduced by 13.8%

enlarged lateral ventricles ( J:302280 )

♂ • lateral ventricles are enlarged in size by 92%

absent corpus callosum ( J:302280 )

♂ • corpus callosum agenesis

decreased dentate gyrus size ( J:302280 )

♂ • dentate gyrus of the hippocampus is smaller

growth/size/body

increased body length ( J:175295 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:175295 )

IMPC - WTSI

decreased circulating total protein level ( J:175295 )

IMPC - WTSI