Phenotypes associated with this allele

• Allele Symbol: Prkcz^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4433718
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Prkcz^tm1a(EUCOMM)Wtsi/Prkcz^tm1a(EUCOMM)Wtsi	B6Brd;B6Dnk;B6N-Tyr^c-Brd Prkcz^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6273145
hm2	Prkcz^tm1a(EUCOMM)Wtsi/Prkcz^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Prkcz^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781706
hm3	Prkcz^tm1a(EUCOMM)Wtsi/Prkcz^tm1a(EUCOMM)Wtsi	involves: C57BL/6 * C57BL/6N	MGI:5790993
ht4	Prkcz^tm1a(EUCOMM)Wtsi/Prkcz^+	B6JTyr;B6N-Prkcz^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781705

Genotype
MGI:6273145

hm1

• Allelic Composition: Prkcz^{tm1a(EUCOMM)Wtsi}/Prkcz^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6Brd;B6Dnk;B6N-Tyr^c-Brd Prkcz^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0061_2_F06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/hair pigmentation ( J:232539 )

• at necropsy (15.9 weeks of age)

pigmentation

abnormal coat/hair pigmentation ( J:232539 )

• at necropsy (15.9 weeks of age)

Genotype
MGI:5781706

hm2

• Allelic Composition: Prkcz^{tm1a(EUCOMM)Wtsi}/Prkcz^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Prkcz^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0061_2_F06

Data Sources

IMPC Data for Prkcz

homeostasis/metabolism

increased circulating alanine transaminase level ( J:175295 )

♂

IMPC - WTSI

increased circulating alkaline phosphatase level ( J:175295 )

♂

IMPC - WTSI

increased circulating aspartate transaminase level ( J:175295 )

♂

IMPC - WTSI

Genotype
MGI:5790993

hm3

• Allelic Composition: Prkcz^{tm1a(EUCOMM)Wtsi}/Prkcz^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: EPD0061_2_F06

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:213427 )

pigmentation

abnormal melanocyte morphology ( J:213427 )

vision/eye

persistence of hyaloid vascular system ( J:213427 )

Genotype
MGI:5781705

ht4

• Allelic Composition: Prkcz^{tm1a(EUCOMM)Wtsi}/Prkcz⁺
• Genetic Background: B6JTyr;B6N-Prkcz^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0061_2_F06

Data Sources

IMPC Data for Prkcz

homeostasis/metabolism

increased circulating iron level ( J:175295 )

IMPC - WTSI