All Phenotypes Marchf5<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Marchf5^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4433802

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5^{tm1a(EUCOMM)Wtsi}	C57BL/6-Marchf5^{tm1a(EUCOMM)Wtsi}	MGI:6276263
hm2	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Marchf5^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:6394325
ht3	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5⁺	C57BL/6-Marchf5^{tm1a(EUCOMM)Wtsi}	MGI:6276262
ht4	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5⁺	C57BL/6N-Marchf5^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5781664

Allelic Composition	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6-Marchf5^{tm1a(EUCOMM)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marchf5^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Marchf5 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:225000 )

Allelic Composition	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Marchf5^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0180_5_B02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marchf5^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Marchf5 mutation (20 available)

Data Sources

IMPC Data for Marchf5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI

Allelic Composition	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5⁺
Genetic Background	C57BL/6-Marchf5^{tm1a(EUCOMM)Wtsi}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marchf5^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Marchf5 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating interferon-beta level ( J:225000 )

• when challenged with replication-competent vesicular stomatitis virus

increased circulating interleukin-6 level ( J:225000 )

• when challenged with replication-competent vesicular stomatitis virus

immune system

increased circulating interferon-beta level ( J:225000 )

• when challenged with replication-competent vesicular stomatitis virus

increased circulating interleukin-6 level ( J:225000 )

• when challenged with replication-competent vesicular stomatitis virus

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:225000 )

• heterozygous mice are resisitant to induced morbidity when challenged with replication-competent vesicular stomatitis virus

• deficient immune cells exhibit low viral replication

mortality/aging

decreased susceptibility to Riboviria infection induced morbidity/mortality ( J:225000 )

• heterozygous mice are resisitant to induced morbidity when challenged with replication-competent vesicular stomatitis virus

• deficient immune cells exhibit low viral replication

Allelic Composition	Marchf5^{tm1a(EUCOMM)Wtsi}/Marchf5⁺
Genetic Background	C57BL/6N-Marchf5^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0180_5_B02

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Marchf5^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Marchf5 mutation (20 available)

Data Sources

IMPC Data for Marchf5

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

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