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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smc3tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4434007
Summary 4 genotypes


Genotype
MGI:6263522
hm1
Allelic
Composition
Smc3tm1a(EUCOMM)Wtsi/Smc3tm1a(EUCOMM)Wtsi
Genetic
Background
B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH
Cell Lines EPD0070_2_G01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3tm1a(EUCOMM)Wtsi mutation (2 available); any Smc3 mutation (47 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5544025
hm2
Allelic
Composition
Smc3tm1a(EUCOMM)Wtsi/Smc3tm1a(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6N
Cell Lines EPD0070_2_G01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3tm1a(EUCOMM)Wtsi mutation (2 available); any Smc3 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die prior to E14.5




Genotype
MGI:5781751
ht3
Allelic
Composition
Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic
Background
B6Dnk;B6Brd;B6N-Tyrc-Brd Smc3tm1a(EUCOMM)Wtsi/WtsiH
Cell Lines EPD0070_2_G01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3tm1a(EUCOMM)Wtsi mutation (2 available); any Smc3 mutation (47 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

growth/size/body

hematopoietic system

integument

pigmentation

skeleton




Genotype
MGI:5544026
ht4
Allelic
Composition
Smc3tm1a(EUCOMM)Wtsi/Smc3+
Genetic
Background
involves: C57BL/6N
Cell Lines EPD0070_2_G01
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smc3tm1a(EUCOMM)Wtsi mutation (2 available); any Smc3 mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced viability at P14

immune system
• helper and cytotoxic T cells

growth/size/body

craniofacial

hematopoietic system
• helper and cytotoxic T cells





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory