Phenotypes associated with this allele

• Allele Symbol: Gsk3a^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4434136
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gsk3a^tm1a(EUCOMM)Wtsi/Gsk3a^tm1a(EUCOMM)Wtsi	B6JTyr;B6N-Gsk3a^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5781634
hm2	Gsk3a^tm1a(EUCOMM)Wtsi/Gsk3a^tm1a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5476705
cx3	Gsk3a^tm1a(EUCOMM)Wtsi/Gsk3a^+ Gsk3b^tm1Grc/Gsk3b^tm1Grc	involves: 129S6/SvEvTac * C57BL/6N	MGI:5476706
cx4	Gsk3a^tm1a(EUCOMM)Wtsi/Gsk3a^+ Gsk3b^tm1Grc/Gsk3b^+	involves: 129S6/SvEvTac * C57BL/6N	MGI:5476707

Genotype
MGI:5781634

hm1

• Allelic Composition: Gsk3a^{tm1a(EUCOMM)Wtsi}/Gsk3a^{tm1a(EUCOMM)Wtsi}
• Genetic Background: B6JTyr;B6N-Gsk3a^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0051_1_H11

Data Sources

IMPC Data for Gsk3a

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased total body fat amount ( J:175295 )

IMPC - WTSI

growth/size/body

decreased body weight ( J:175295 )

IMPC - WTSI

decreased body length ( J:175295 )

♀

IMPC - WTSI

homeostasis/metabolism

decreased circulating glucose level ( J:175295 )

IMPC - WTSI

decreased circulating glycerol level ( J:175295 )

IMPC - WTSI

skeleton

decreased lumbar vertebrae number ( J:175295 )

♂

IMPC - WTSI

increased sacral vertebrae number ( J:175295 )

♂

IMPC - WTSI

Genotype
MGI:5476705

hm2

• Allelic Composition: Gsk3a^{tm1a(EUCOMM)Wtsi}/Gsk3a^{tm1a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N

craniofacial

craniofacial phenotype ( J:195008 )

N • mice exhibit normal palate closure

wide metopic suture ( J:195008 )

• subtly wider interfrontal suture at E17.5 that may be due to normal developmental variation

skeleton

wide metopic suture ( J:195008 )

• subtly wider interfrontal suture at E17.5 that may be due to normal developmental variation

Genotype
MGI:5476706

cx3

• Allelic Composition: Gsk3a^{tm1a(EUCOMM)Wtsi}/Gsk3a⁺; Gsk3b^tm1Grc/Gsk3b^tm1Grc
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

craniofacial

cleft palate ( J:195008 )

• varied

digestive/alimentary system

cleft palate ( J:195008 )

• varied

growth/size/body

cleft palate ( J:195008 )

• varied

Genotype
MGI:5476707

cx4

• Allelic Composition: Gsk3a^{tm1a(EUCOMM)Wtsi}/Gsk3a⁺; Gsk3b^tm1Grc/Gsk3b⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6N

craniofacial

cleft palate ( J:195008 )

• in 1 of 5 mice

digestive/alimentary system

cleft palate ( J:195008 )

• in 1 of 5 mice

growth/size/body

cleft palate ( J:195008 )

• in 1 of 5 mice