All Phenotypes Cyfip2<tm1a(EUCOMM)Wtsi> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cyfip2^{tm1a(EUCOMM)Wtsi}
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4434196

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyfip2^{tm1a(EUCOMM)Wtsi}/Cyfip2^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Cyfip2^{tm1a(EUCOMM)Wtsi}	MGI:5527329
hm2	Cyfip2^{tm1a(EUCOMM)Wtsi}/Cyfip2^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Cyfip2^{tm1a(EUCOMM)Wtsi}/Wtsi	MGI:5631023
ht3	Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi}	C57BL/6N-Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi}	MGI:5527330

Allelic Composition	Cyfip2^{tm1a(EUCOMM)Wtsi}/Cyfip2^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Cyfip2^{tm1a(EUCOMM)Wtsi}
Cell Lines	EPD0436_2_A04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Cyfip2 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:203183 )

• mice die within hours of birth

Allelic Composition	Cyfip2^{tm1a(EUCOMM)Wtsi}/Cyfip2^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Cyfip2^{tm1a(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0436_2_B03

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Cyfip2 mutation (61 available)

Data Sources

IMPC Data for Cyfip2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal inferior vena cava valve morphology ( J:239583 )

DMDD

bicuspid aortic valve ( J:239583 )

DMDD

homeostasis/metabolism

subcutaneous edema ( J:239583 )

DMDD

integument

subcutaneous edema ( J:239583 )

DMDD

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

nervous system

abnormal hindbrain morphology ( J:239583 )

DMDD

normal phenotype

no abnormal phenotype detected ( J:239583 )

DMDD

renal/urinary system

duplex kidney ( J:239583 )

DMDD

bifid ureter ( J:239583 )

DMDD

dilated ureter ( J:239583 )

DMDD

Allelic Composition	Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi}
Genetic Background	C57BL/6N-Cyfip2^M1N/Cyfip2^{tm1a(EUCOMM)Wtsi}
Cell Lines	EPD0436_2_A04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cyfip2^M1N mutation (1 available); any Cyfip2 mutation (61 available)
Cyfip2^{tm1a(EUCOMM)Wtsi} mutation (2 available); any Cyfip2 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

enhanced behavioral response to cocaine ( J:203183 )

• compared with Cyfip2^m1N homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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