Phenotypes associated with this allele

• Allele Symbol: Fbxo11^{tm2a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 2a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4434283
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fbxo11^tm2a(EUCOMM)Wtsi/Fbxo11^tm2a(EUCOMM)Wtsi	involves: C57BL/6N	MGI:5903886

Genotype
MGI:5903886

hm1

• Allelic Composition: Fbxo11^{tm2a(EUCOMM)Wtsi}/Fbxo11^{tm2a(EUCOMM)Wtsi}
• Genetic Background: involves: C57BL/6N
• Cell Lines: EPD0248_1_H03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:220308 )

• newborn homozygous mutants die shortly after birth

integument

decreased hair follicle number ( J:220308 )

• the number of hair follicles is significantly decreased in neonatal epidermis

absent keratohyalin granules ( J:220308 )

• keratohyalin granules are virtually absent in the stratum granulosum

epidermal hyperplasia ( J:220308 )

• increased epidermal thickness apparently results from keratinocyte hyperplasia

thick epidermis ( J:220308 )

• newborn pups exhibit thicker epidermis than wild-type pups

homeostasis/metabolism

abnormal protein level ( J:220308 )

• Snai1/2 protein levels are significantly increased whereas E-cadherin expression is strongly decreased in protein extracts from the back skin of newborn pups

• Snai1/2 proteins accumulate primarily in the basal layer of the developing epidermis in late stage (E18.5) embryos