Phenotypes associated with this allele

• Allele Symbol: Sra1^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4434735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sra1^tm1a(EUCOMM)Hmgu/Sra1^tm1a(EUCOMM)Hmgu	involves: C57BL/6J * C57BL/6N	MGI:5588690

Genotype
MGI:5588690

hm1

• Allelic Composition: Sra1^{tm1a(EUCOMM)Hmgu}/Sra1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6J * C57BL/6N
• Cell Lines: HEPD0528_3_F03

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

decreased susceptibility to diet-induced obesity ( J:214131 )

♂ • mice are protected against diet-induced obesity and have decreased expression of adipocyte genes

adipose tissue

decreased brown adipose tissue amount ( J:214131 )

♂ • mice fed a high-fat diet show reduced interscapular brown adipose tissue mass

decreased subcutaneous adipose tissue amount ( J:214131 )

♂ • mice fed a high-fat diet show reduced subcutaneous white fat mass

decreased total body fat amount ( J:214131 )

♂ • mice show reduced % fat mass on a high-fat diet, with increased % lean mass

decreased brown fat cell size ( J:214131 )

♂ • mice fed a high-fat diet show reduced brown adipocyte size

decreased white fat cell size ( J:214131 )

♂ • mice fed a high-fat diet exhibit small adipocytes in epididymal white fat

abnormal epididymal fat pad morphology ( J:214131 )

♂ • mice fed a high-fat diet show reduced epididymal white fat on a high-fat diet

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:214131 )

♂N • energy expenditure is unchanged and mice show normal locomotor activity during high-fat diet feeding

decreased susceptibility to diet-induced obesity ( J:214131 )

♂ • mice are protected against diet-induced obesity and have decreased expression of adipocyte genes

decreased circulating insulin level ( J:214131 )

♂ • mice fed a high-fat diet exhibit reduced insulin levels with no change in fasting blood glucose

decreased circulating tumor necrosis factor level ( J:214131 )

♂ • mice fed a high-fat diet show reduced plasma TNF-alpha levels, however IL-6 levels are unchanged

improved glucose tolerance ( J:214131 )

♂ • mice fed a high-fat diet exhibit improved glucose tolerance following intraperitoneal glucose challenge

increased insulin sensitivity ( J:214131 )

♂ • mice fed a high-fat diet exhibit marked hypoglycemia following insulin challenge indicating increased insulin sensitivity

decreased liver free fatty acids level ( J:214131 )

♂ • liver free fatty acid levels are 54% lower in high-fat diet fed mutants than in controls

decreased liver triglyceride level ( J:214131 )

♂ • liver triglyceride levels are 61% lower in high-fat diet fed mutants than in controls

immune system

decreased circulating tumor necrosis factor level ( J:214131 )

♂ • mice fed a high-fat diet show reduced plasma TNF-alpha levels, however IL-6 levels are unchanged

integument

decreased subcutaneous adipose tissue amount ( J:214131 )

♂ • mice fed a high-fat diet show reduced subcutaneous white fat mass

liver/biliary system

abnormal liver morphology ( J:214131 )

♂ • mice on a high-fat diet show reduced liver mass

decreased liver free fatty acids level ( J:214131 )

♂ • liver free fatty acid levels are 54% lower in high-fat diet fed mutants than in controls

decreased liver triglyceride level ( J:214131 )

♂ • liver triglyceride levels are 61% lower in high-fat diet fed mutants than in controls

decreased liver weight ( J:214131 )

♂ • mice show a 30% reduction in liver weight after high-fat diet feeding

decreased susceptibility to diet-induced hepatic steatosis ( J:214131 )

♂ • mice fed a high-fat diet show greatly reduced lipid droplets in the livers