Phenotypes associated with this allele

• Allele Symbol: Plvap^{tm1e(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4434827
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plvap^tm1e(EUCOMM)Hmgu/Plvap^tm1e(EUCOMM)Hmgu	C57BL/6N-Plvap^tm1e(EUCOMM)Hmgu	MGI:5529619
cx2	Plvap^tm1e(EUCOMM)Hmgu/Plvap^tm1e(EUCOMM)Hmgu Tg(TIE2GFP)287Sato/0	involves: C57BL/6N * FVB/N	MGI:5529620

Genotype
MGI:5529619

hm1

• Allelic Composition: Plvap^{tm1e(EUCOMM)Hmgu}/Plvap^{tm1e(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Plvap^{tm1e(EUCOMM)Hmgu}
• Cell Lines: HEPD0550_4_E12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:203907 )

• Background Sensitivity: no mice on a coisogenic C57BL/6N background are observed after E17.5 unlike mice on a mixed C57BL/6N and FVB/N background that survive up to 4 weeks

cardiovascular system

abnormal capillary morphology ( J:203907 )

• capillaries lack caveolae with stomatal diaphragms and exhibit incomplete endothelial walls comapred with wild-type mice

ventricular septal defect ( J:203907 )

• at E16.5

thin ventricular wall ( J:203907 )

• at E16.5

hemorrhage ( J:203907 )

• at E16.5 with accumulation of extracellular erythrocytes

• extensive, non-specific focal at E17.5

hematopoietic system

anemia ( J:203907 )

abnormal erythrocyte morphology ( J:203907 )

• accumulation of extracellular erythrocytes at E16.5

increased nucleated erythrocyte cell number ( J:203907 )

• at E14.5, E16.5 and E17.5

homeostasis/metabolism

edema ( J:203907 )

• severe total body at E17.5

skin edema ( J:203907 )

• extending from the neck to the lower back at E16.5 with accumulation of extracellular erythrocytes

integument

skin edema ( J:203907 )

• extending from the neck to the lower back at E16.5 with accumulation of extracellular erythrocytes

pallor ( J:203907 )

Genotype
MGI:5529620

cx2

• Allelic Composition: Plvap^{tm1e(EUCOMM)Hmgu}/Plvap^{tm1e(EUCOMM)Hmgu}; Tg(TIE2GFP)287Sato/0
• Genetic Background: involves: C57BL/6N * FVB/N
• Cell Lines: HEPD0550_4_E12

mortality/aging

premature death ( J:203907 )

• Background Sensitivity: mice on a mixed C57BL/6N and FVB/N background survive up to 4 weeks compared with mice on a coisogenic C57BL/6N background that do not survive beyond E17.5

cardiovascular system

cardiovascular system phenotype ( J:203907 )

N • Background Sensitivity: mice on a mixed C57BL/6N and FVB/N background do not exhibit ventricular septal defects unlike mice on a coisogenic C57BL/6N background

abnormal capillary morphology ( J:203907 )

• interstitial peritubular capillaries exhibit thicker endothelial wall and lack fenestrae, diaphragms and caveolae compared with wild-type mice

endocrine/exocrine glands

abnormal pancreas morphology ( J:203907 )

• larger interstitial spaces than in wild-type mice

small pancreas ( J:203907 )

• at 3 weeks

growth/size/body

decreased body size ( J:203907 )

• at P15

hematopoietic system

anemia ( J:203907 )

• indicated by pale kidney and pancreas

small spleen ( J:203907 )

• at 3 weeks

renal/urinary system

small kidney ( J:203907 )

• at 3 weeks

pale kidney ( J:203907 )

homeostasis/metabolism

edema ( J:203907 )

• on the neck and back at E17.5

limbs/digits/tail

kinked tail ( J:203907 )

• at P15

immune system

small spleen ( J:203907 )

• at 3 weeks