Phenotypes associated with this allele

• Allele Symbol: Bap1^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4436674
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bap1^tm1a(EUCOMM)Hmgu/Bap1^tm1a(EUCOMM)Hmgu	C57BL/6N-Bap1^tm1a(EUCOMM)Hmgu/Wtsi	MGI:5700827
ht2	Bap1^tm1a(EUCOMM)Hmgu/Bap1^+	C57BL/6N-Bap1^tm1a(EUCOMM)Hmgu/Wtsi	MGI:5705958

Genotype
MGI:5700827

hm1

• Allelic Composition: Bap1^{tm1a(EUCOMM)Hmgu}/Bap1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Bap1^{tm1a(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0526_2_G01

Data Sources

IMPC Data for Bap1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal chorion morphology ( J:261316 )

• unpatterned chorion at E9.5

abnormal placenta morphology ( J:261316 )

• branching morphology defect at E9.5

abnormal trophoblast layer morphology ( J:261316 )

• small or absent trophoblast compartment at E9.5

• biased differentiation (diploid/polyploid trophoblast)

abnormal visceral yolk sac morphology ( J:261316 )

• yolk sac abnormalities

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:261316 )

• fewer than the expected numbers of embryos are obtained at E9.5

preweaning lethality, complete penetrance ( J:211773 )

IMPC - WTSI

lethality throughout fetal growth and development, complete penetrance ( J:261316 )

• complete lethality at E14.5

Genotype
MGI:5705958

ht2

• Allelic Composition: Bap1^{tm1a(EUCOMM)Hmgu}/Bap1⁺
• Genetic Background: C57BL/6N-Bap1^{tm1a(EUCOMM)Hmgu}/Wtsi
• Cell Lines: HEPD0526_2_G01

Data Sources

IMPC Data for Bap1

integument

abnormal vibrissa morphology ( J:211773 )

IMPC - WTSI