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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxp3tm8Ayr
targeted mutation 8, Alexander Y Rudensky
MGI:4436759
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Foxp3tm8Ayr/Foxp3+ B6.129-Foxp3tm8Ayr MGI:4436861
ot2
 		Foxp3tm8Ayr/Y B6.129-Foxp3tm8Ayr MGI:4436862


Genotype
MGI:4436861
ht1
Allelic
Composition		 Foxp3tm8Ayr/Foxp3+
Genetic
Background		 B6.129-Foxp3tm8Ayr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm8Ayr mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:157377 )
• heterozygous female mice are healthy




Genotype
MGI:4436862
ot2
Allelic
Composition		 Foxp3tm8Ayr/Y
Genetic
Background		 B6.129-Foxp3tm8Ayr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3tm8Ayr mutation (0 available); any Foxp3 mutation (58 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:157377 )
• males die by around 4 weeks

immune system
autoimmune response ( J:157377 )
• male mice develope severe autoimmunity




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory