Phenotypes associated with this allele

• Allele Symbol: Ffar2^tm2Lex
• Allele Name: targeted mutation 2, Lexicon Genetics
• Allele ID: MGI:4436772
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ffar2^tm2Lex/Ffar2^tm2Lex	involves: 129S7/SvEvBrd * C57BL/6	MGI:4436773

Genotype
MGI:4436773

hm1

• Allelic Composition: Ffar2^tm2Lex/Ffar2^tm2Lex
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:157383 )

• following addition of 4% dextrane sodium sulfate to the drinking water, mice die between days 6 and 8 from sepsis, whereas all wild-type mice survived until day 10 when the experiment was stopped

digestive/alimentary system

rectal hemorrhage ( J:157383 )

• less rectal bleeding in repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type

abnormal colon morphology ( J:157383 )

• significantly decreased endoscopic score following addition of 4% dextrane sodium sulfate to the drinking water

• significantly decreased endoscopic score and increased colon length after repeated administrations of 2% dextrane sodium sulfate for 30 days

abnormal defecation ( J:157383 )

• less diarrhea in mice administered 2% dextrane sodium sulfate for 30 days compared to wild-type

decreased susceptibility to induced colitis ( J:157383 )

• 4% dextrane sodium sulfate (DSS) added to the drinking water induces less intestinal damage although disease activity index is elevated after day 6 due to sepsis

• repeated administrations of 2% dextrane sodium sulfate for 30 days results in significantly milder disease activity index compared to similarly treated wild-type mice

large intestinal inflammation ( J:157383 )

• distal colon shows reduced tissue damage and inflammatory cell infiltration after 4% dextrane sodium sulfate added to the drinking water

• repeated administrations of 2% dextrane sodium sulfate for 30 days results in less inflammatory mucosal signs

immune system

impaired neutrophil chemotaxis ( J:157383 )

• propionate or butyrate stimulation does not increase chemotactic migration as is observed in wild-type mice

abnormal neutrophil morphology ( J:157383 )

• myeloperoxidase activity levels are significantly reduced during treatment with 4% dextrane sodium sulfate in homogenized colonic tissue

• the amount of polymorphonuclear leukocytes in the submucosal tissue is significantly reduced compared with wild-type mice after 4% dextrane sodium sulfate added to the drinking water

• L-selectin protein levels on the cell surface of polymorphonuclear are elevated compared to wild-type after 1 hour of stimulation with short chain fatty acids.

abnormal cytokine level ( J:157383 )

decreased circulating tumor necrosis factor level ( J:157383 )

• TNF-alpha concentrations are diminished after repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type

increased circulating tumor necrosis factor level ( J:157383 )

• TNF-alpha levels are highly elevated during treatment with 4% dextrane sodium sulfate in the drinking water

decreased tumor necrosis factor secretion ( J:157383 )

• level of TNF-alpha in colonic organ cultures is significantly reduced

abnormal inflammatory response ( J:157383 )

• less inflammation in animals on day 6 after 4% dextrane sodium sulfate added to the drinking water

decreased susceptibility to induced colitis ( J:157383 )

• 4% dextrane sodium sulfate (DSS) added to the drinking water induces less intestinal damage although disease activity index is elevated after day 6 due to sepsis

• repeated administrations of 2% dextrane sodium sulfate for 30 days results in significantly milder disease activity index compared to similarly treated wild-type mice

large intestinal inflammation ( J:157383 )

• distal colon shows reduced tissue damage and inflammatory cell infiltration after 4% dextrane sodium sulfate added to the drinking water

• repeated administrations of 2% dextrane sodium sulfate for 30 days results in less inflammatory mucosal signs

sepsis ( J:157383 )

• 16S rDNA bacterial signatures of Clostridium spp in liver and spleen after 4% dextrane sodium sulfate added to the drinking water

growth/size/body

decreased body weight ( J:157383 )

• more weight loss in response to 4% dextrane sodium sulfate added to the drinking water

increased body weight ( J:157383 )

• repeated administrations of 2% dextrane sodium sulfate for 30 days results in less weight loss than in wild-type

cardiovascular system

rectal hemorrhage ( J:157383 )

• less rectal bleeding in repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type

hematopoietic system

impaired neutrophil chemotaxis ( J:157383 )

• propionate or butyrate stimulation does not increase chemotactic migration as is observed in wild-type mice

abnormal neutrophil morphology ( J:157383 )

• myeloperoxidase activity levels are significantly reduced during treatment with 4% dextrane sodium sulfate in homogenized colonic tissue

• the amount of polymorphonuclear leukocytes in the submucosal tissue is significantly reduced compared with wild-type mice after 4% dextrane sodium sulfate added to the drinking water

• L-selectin protein levels on the cell surface of polymorphonuclear are elevated compared to wild-type after 1 hour of stimulation with short chain fatty acids.

homeostasis/metabolism

abnormal cytokine level ( J:157383 )

decreased circulating tumor necrosis factor level ( J:157383 )

• TNF-alpha concentrations are diminished after repeated administrations of 2% dextrane sodium sulfate for 30 days compared to wild-type

increased circulating tumor necrosis factor level ( J:157383 )

• TNF-alpha levels are highly elevated during treatment with 4% dextrane sodium sulfate in the drinking water

increased susceptibility to xenobiotic induced morbidity/mortality ( J:157383 )

• following addition of 4% dextrane sodium sulfate to the drinking water, mice die between days 6 and 8 from sepsis, whereas all wild-type mice survived until day 10 when the experiment was stopped

cellular

impaired neutrophil chemotaxis ( J:157383 )

• propionate or butyrate stimulation does not increase chemotactic migration as is observed in wild-type mice