All Phenotypes H2-Ab1<b-tm1.1Sish> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

H2-Ab1^b-tm1.1Sish
targeted mutation 1.1, Satoshi Ishido
MGI:4436864

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	H2-Ab1^b-tm1.1Sish/H2-Ab1^b-tm1.1Sish	involves: 129S1/Sv * 129X1/SvJ	MGI:4436874

Allelic Composition	H2-Ab1^b-tm1.1Sish/H2-Ab1^b-tm1.1Sish
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1^b-tm1.1Sish mutation (1 available); any H2-Ab1 mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal dendritic cell physiology ( J:157516 )

• CD11c+ dendritic cells induce less proliferation of CD4+ T cell expressing Tg(TcraTcrb)425Cbn compared with wild-type cells

decreased interleukin-12 secretion ( J:157516 )

• in CD8+ and CD8- dendritic cells following LPS stimulation

decreased tumor necrosis factor secretion ( J:157516 )

• in CD8+ and CD8- dendritic cells following LPS stimulation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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