All Phenotypes Nr4a2<tm1.1Pcn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Nr4a2^tm1.1Pcn
targeted mutation 1.1, Pierre Chambon
MGI:4437024

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn	Not Specified	MGI:4437055
cn2	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Slc6a3^tm1(cre)Lrsn/Slc6a3^tm1(cre)Lrsn	involves: 129S1/Sv * 129X1/SvJ	MGI:4437054
cn3	Nr4a2^tm1.1Pcn/Nr4a2⁺ Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5547375
cn4	Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn	involves: 129S1/Sv * 129X1/SvJ	MGI:5547376
cn5	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺	involves: C57BL/6 * C57BL/6NTac	MGI:5547377
cn6	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Tg(Lck-cre)1Jtak/0	Not Specified	MGI:5547378

Allelic Composition	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2^tm1.1Pcn mutation (0 available); any Nr4a2 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:157098 )

N	• injection of adenovirus expressing cre do not alter brain morphology, expression of midbrain dopamine neuron markers, or microglia activation

decreased dopaminergic neuron number ( J:157098 )

• mice injected with an adenovirus expressing cre exhibit a progressive decrease in dopaminergic neurons compared with wild-type mice

behavior/neurological

akinesia ( J:157098 )

• 3 to 4 months after injection with an adenovirus expressing cre, mice exhibit impaired performance in a stepping test compared with wild-type mice

homeostasis/metabolism

decreased dopamine level ( J:157098 )

• in the dorsolateral striatum and areas innervated by scattered ventral tegmental area of mice injected with an adenovirus expressing cre

Allelic Composition	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Slc6a3^tm1(cre)Lrsn/Slc6a3^tm1(cre)Lrsn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2^tm1.1Pcn mutation (0 available); any Nr4a2 mutation (44 available)
Slc6a3^tm1(cre)Lrsn mutation (1 available); any Slc6a3 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality at weaning, complete penetrance ( J:157098 )

• mice do not survive beyond 3 weeks

• however, leaving pups with mothers improves perinatal survival beyond 3 weeks

nervous system

abnormal dopaminergic neuron morphology ( J:157098 )

• expression of midbrain dopamine neuron markers is lost compared to in wild-type mice

neuron degeneration ( J:157098 )

• mice exhibit a rapid loss of substantia nigra pars compacta cell bodies with only scattered ventral tegmental area neurons remaining compared with wild-type mice

behavior/neurological

decreased vertical activity ( J:157098 )

• at 4 and 14 months

decreased locomotor activity ( J:157098 )

hyperactivity ( J:157098 )

• L-DOPA-treated mice exhibit hyperactivity unlike similarly treated wild-type mice

increased stereotypic behavior ( J:157098 )

• L-DOPA-treated mice exhibit repetitive behaviors (including repetitive gnawing, excessive grooming, and self-injury) unlike similarly treated wild-type mice

homeostasis/metabolism

decreased dopamine level ( J:157098 )

• at P1, striatal dopamine levels are decreased to 14% of wild-type

• at P14, the ratio of homovanillic acid (HVA) to dopamine is increased indicating increased dopamine turnover compared to in wild-type mice

• at P60, striatal dopamine levels are almost completely lost unlike in wild-type mice

• at P60, dopamine levels are more severely decreased in the caudate putamen compared to in the nucleus accumbens

increased serotonin level ( J:157098 )

• serotonin levels in the caudate putamen and nucleus accumbens are increased compared to in wild-type mice

abnormal response/metabolism to endogenous compounds ( J:157098 )

• L-DOPA-treated mice exhibit hyperactivity and repetitive behaviors unlike similarly treated wild-type mice

growth/size/body

decreased body size ( J:157098 )

• at 2 months, mice left with their mothers after weaning are 40% smaller than wild-type mice

Allelic Composition	Nr4a2^tm1.1Pcn/Nr4a2⁺ Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3^{tm4(YFP/icre)Ayr} mutation (2 available); any Foxp3 mutation (58 available)
Nr4a2^tm1.1Pcn mutation (0 available); any Nr4a2 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal regulatory T cell morphology ( J:205658 )

• Treg cells are not properly maintained

hematopoietic system

abnormal regulatory T cell morphology ( J:205658 )

• Treg cells are not properly maintained

Allelic Composition	Foxp3^{tm4(YFP/icre)Ayr}/Foxp3⁺ Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal regulatory T cell morphology ( J:205658 )

• regulatory T cells are not properly maintained

abnormal regulatory T cell physiology ( J:205658 )

• slightly attenuated suppressive activity

• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells

hematopoietic system

abnormal regulatory T cell morphology ( J:205658 )

• regulatory T cells are not properly maintained

abnormal regulatory T cell physiology ( J:205658 )

• slightly attenuated suppressive activity

• in a transfer model of colitis, regulatory T cells fail to inhibit wasting disease and colitis compared with wild-type cells

Allelic Composition	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte}/Gt(ROSA)26Sor⁺
Genetic Background	involves: C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(cre/ESR1)Arte} mutation (2 available); any Gt(ROSA)26Sor mutation (993 available)
Nr4a2^tm1.1Pcn mutation (0 available); any Nr4a2 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 1 cell differentiation ( J:205658 )

• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment

abnormal T-helper 17 cell differentiation ( J:205658 )

• reduced under Th17-skewing conditions following tamoxifen-treatment

abnormal regulatory T cell morphology ( J:205658 )

• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:205658 )

• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions following tamoxifen-treatment

abnormal T-helper 17 cell differentiation ( J:205658 )

• reduced under Th17-skewing conditions following tamoxifen-treatment

abnormal regulatory T cell morphology ( J:205658 )

• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions following tamoxifen-treatment

Allelic Composition	Nr4a2^tm1.1Pcn/Nr4a2^tm1.1Pcn Tg(Lck-cre)1Jtak/0
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr4a2^tm1.1Pcn mutation (0 available); any Nr4a2 mutation (44 available)
Tg(Lck-cre)1Jtak mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:205658 )

• more than half of mice

immune system

immune system phenotype ( J:205658 )

N	• surviving mice exhibit no auto-immune disease symptoms up to 4 months of age • mice exhibit normal numbers of regulatory T cells in the thymus and spleen

increased susceptibility to induced colitis ( J:205658 )

• DSS-treated mice exhibit accelerated body weight loss, severe intestinal inflammation, increased Th1 cells and attenuated increase of regulatory T cells in the colon and cecum lamina propria compared with control mice

abnormal T-helper 1 cell differentiation ( J:205658 )

• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions

abnormal T-helper 17 cell differentiation ( J:205658 )

• reduced under Th17-skewing conditions

increased CD4-positive, alpha-beta T cell number ( J:205658 )

• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells

increased T-helper 1 cell number ( J:205658 )

• in DSS-treated mice

abnormal regulatory T cell morphology ( J:205658 )

• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions

decreased regulatory T cell number ( J:205658 )

• in DSS-treated mice

digestive/alimentary system

increased susceptibility to induced colitis ( J:205658 )

growth/size/body

increased susceptibility to weight loss ( J:205658 )

• accelerated in DSS-treated mice

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:205658 )

• increased under Th1-, Th17- and induced regulatory T cell-skewing conditions

abnormal T-helper 17 cell differentiation ( J:205658 )

• reduced under Th17-skewing conditions

increased CD4-positive, alpha-beta T cell number ( J:205658 )

• CD44highCD62Llow-activated and IFN-gamma CD4+ T cells

increased T-helper 1 cell number ( J:205658 )

• in DSS-treated mice

abnormal regulatory T cell morphology ( J:205658 )

• reduced regulatory T cell differentiation under induced regulatory T cell-skewing conditions

decreased regulatory T cell number ( J:205658 )

• in DSS-treated mice

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