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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mirc30tm1.1Rdf
targeted mutation 1.1, Riccardo Dalla-Favera
MGI:4437043
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Cd19tm1(cre)Cgn/Cd19+
Mirc30tm1.1Rdf/Mirc30tm1.1Rdf 		involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6 MGI:4437066


Genotype
MGI:4437066
cn1
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Mirc30tm1.1Rdf/Mirc30tm1.1Rdf
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Mirc30tm1.1Rdf mutation (1 available); any Mirc30 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:156946 )
• fraction of mice have histological features of small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL)
increased B cell derived lymphoma incidence ( J:156946 )
• some of the CD5 negative tumors showed a mature B cell phenotype histologically reminiscent of human diffuse large B cell lymphoma, non-Hodgkin lymphoma
• a minority of CD5 negative tumors showed plasmacytic features similar to lymphoplasmacytic lymphoma

hematopoietic system
increased B cell number ( J:156946 )
• monoclonal B cell lymphocytosis in some mice at 15 - 18 months of age
increased B-1a cell number ( J:156946 )
• at 15-18 months increased clonal population in the peripheral blood
increased spleen white pulp amount ( J:156946 )
• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

immune system
increased B cell number ( J:156946 )
• monoclonal B cell lymphocytosis in some mice at 15 - 18 months of age
increased B-1a cell number ( J:156946 )
• at 15-18 months increased clonal population in the peripheral blood
increased spleen white pulp amount ( J:156946 )
• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory