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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Resttm1.1Yasu
targeted mutation 1.1, Yasuhiro Yamada
MGI:4437069
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Resttm1.1Yasu/Resttm1.2Yasu
Alpltm1(cre)Nagy/Alpl+ 		involves: 129 * C57BL/6 * C57BL/6J MGI:5450879
cn2
 		Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J MGI:6241534
cn3
 		Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J MGI:6241488
cn4
 		Resttm1.1Yasu/Rest+
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J MGI:6241489
cn5
 		Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Dct-lacZ)A12Jkn/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:6241535
cn6
 		Resttm1.1Yasu/Rest+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Dct-lacZ)A12Jkn/0 		involves: 129S4/SvJae * C57BL/6 * CBA MGI:6241536
cn7
 		Resttm1.1Yasu/Resttm1.1Yasu
Tg(Tyr-cre)1Lru/Y 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:6241524
cn8
 		Resttm1.1Yasu/Rest+
Tg(KRT14-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:6241529
cn9
 		Resttm1.1Yasu/Resttm1.1Yasu
Tg(KRT14-cre)1Cgn/0 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:6241532
cn10
 		Resttm1.1Yasu/Rest+
Tg(Tyr-cre)1Lru/Y 		involves: 129S4/SvJae * C57BL/6 * DBA/2 MGI:6241517
cn11
 		Resttm1.1Yasu/Rest+
Tg(Mpz-cre)26Mes/0 		involves: 129S4/SvJae * C57BL/6 * FVB/NTac MGI:6241492
cn12
 		Resttm1.1Yasu/Resttm1.1Yasu
Tg(Mpz-cre)26Mes/0 		involves: 129S4/SvJae * C57BL/6 * FVB/NTac MGI:6241493
cn13
 		Dcttm1(cre)Bee/Dct+
Resttm1.1Yasu/Rest+ 		involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:6241494
cn14
 		Dcttm1(cre)Bee/Dct+
Resttm1.1Yasu/Resttm1.1Yasu 		involves: 129/Sv * 129S4/SvJae * C57BL/6 MGI:6241506


Genotype
MGI:5450879
cn1
Allelic
Composition		 Resttm1.1Yasu/Resttm1.2Yasu
Alpltm1(cre)Nagy/Alpl+
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (352 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Resttm1.2Yasu mutation (0 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:190948 )
N
• despite the decrease in primordial germ cell numbers, germ cell numbers at E18.5 and fertility of adult mice are similar to wild-type controls
decreased primordial germ cell number ( J:190948 )
• at E12.5 in the genital ridge
increased primordial germ cell apoptosis ( J:190948 )
• increase in the ratio of apoptotic to viable PGCs at E11.5

cellular
decreased primordial germ cell number ( J:190948 )
• at E12.5 in the genital ridge
increased primordial germ cell apoptosis ( J:190948 )
• increase in the ratio of apoptotic to viable PGCs at E11.5




Genotype
MGI:6241534
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal melanoblast morphology ( J:230341 )
• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Resttm1.1Yasu allele

nervous system
abnormal melanoblast morphology ( J:230341 )
• at E14.5, the number of LacZ+ neural crest cell-derived cells in the skin is lower in both the head and belly regions than that in NCC-specific heterozygous knockout littermates carrying only one Resttm1.1Yasu allele




Genotype
MGI:6241488
cn3
Allelic
Composition		 Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:230341 )
• mice die within 48 hrs of birth

nervous system
nervous system phenotype ( J:230341 )
N
• at E16.5, E18.5 and P0, no significant differences are observed in the number or distribution pattern of melanoblasts in the epidermis of vibrissae, back or abdominal skin relative to control mice




Genotype
MGI:6241489
cn4
Allelic
Composition		 Resttm1.1Yasu/Rest+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:230341 )
N
• mice are viable and survive to adulthood

pigmentation
belly spot ( J:230341 )
• ~60% of mice exhibit a white belly spot of variable size ranging from a few white hairs to a white spot that is ~1 cm in diameter; in contrast, only ~15% of control mice carrying the transgene alone form an extremely small, striated white-haired area on the belly

integument
belly spot ( J:230341 )
• ~60% of mice exhibit a white belly spot of variable size ranging from a few white hairs to a white spot that is ~1 cm in diameter; in contrast, only ~15% of control mice carrying the transgene alone form an extremely small, striated white-haired area on the belly

nervous system
nervous system phenotype ( J:230341 )
N
• at E16.5, E18.5 and P0, no significant differences are observed in the number or distribution pattern of melanoblasts in the epidermis of vibrissae, back or abdominal skin relative to control mice




Genotype
MGI:6241535
cn5
Allelic
Composition		 Resttm1.1Yasu/Resttm1.1Yasu
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Dct-lacZ)A12Jkn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal melanoblast morphology ( J:230341 )
• at E12.5 and E14.5, the number of Dct-LacZ+ cells in the belly region is significantly lower than that in control mice
• at E17.5, the distribution pattern of LacZ+ cells is altered in skin from the abdomen, but not from the back or head

nervous system
abnormal melanoblast morphology ( J:230341 )
• at E12.5 and E14.5, the number of Dct-LacZ+ cells in the belly region is significantly lower than that in control mice
• at E17.5, the distribution pattern of LacZ+ cells is altered in skin from the abdomen, but not from the back or head




Genotype
MGI:6241536
cn6
Allelic
Composition		 Resttm1.1Yasu/Rest+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tg(Dct-lacZ)A12Jkn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Dct-lacZ)A12Jkn mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
abnormal melanoblast morphology ( J:230341 )
• adult mice show a marked reduction in the number of Dct-LacZ+ melanoblasts and/or melanocytes in the white spot of abdominal skin

nervous system
abnormal melanoblast morphology ( J:230341 )
• adult mice show a marked reduction in the number of Dct-LacZ+ melanoblasts and/or melanocytes in the white spot of abdominal skin




Genotype
MGI:6241524
cn7
Allelic
Composition		 Resttm1.1Yasu/Resttm1.1Yasu
Tg(Tyr-cre)1Lru/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Tyr-cre)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:230341 )
N
• mice never form white spots including on the belly region




Genotype
MGI:6241529
cn8
Allelic
Composition		 Resttm1.1Yasu/Rest+
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:230341 )
N
• mice never form white spots




Genotype
MGI:6241532
cn9
Allelic
Composition		 Resttm1.1Yasu/Resttm1.1Yasu
Tg(KRT14-cre)1Cgn/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(KRT14-cre)1Cgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:230341 )
N
• mice never form white spots




Genotype
MGI:6241517
cn10
Allelic
Composition		 Resttm1.1Yasu/Rest+
Tg(Tyr-cre)1Lru/Y
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Tyr-cre)1Lru mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:230341 )
N
• mice never form white spots including on the belly region




Genotype
MGI:6241492
cn11
Allelic
Composition		 Resttm1.1Yasu/Rest+
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:230341 )
N
• mice never form white spots including on the belly region




Genotype
MGI:6241493
cn12
Allelic
Composition		 Resttm1.1Yasu/Resttm1.1Yasu
Tg(Mpz-cre)26Mes/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
Tg(Mpz-cre)26Mes mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:230341 )
N
• mice never form white spots including on the belly region




Genotype
MGI:6241494
cn13
Allelic
Composition		 Dcttm1(cre)Bee/Dct+
Resttm1.1Yasu/Rest+
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcttm1(cre)Bee mutation (1 available); any Dct mutation (35 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:230341 )
N
• mice never form white spots including on the belly region




Genotype
MGI:6241506
cn14
Allelic
Composition		 Dcttm1(cre)Bee/Dct+
Resttm1.1Yasu/Resttm1.1Yasu
Genetic
Background		 involves: 129/Sv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dcttm1(cre)Bee mutation (1 available); any Dct mutation (35 available)
Resttm1.1Yasu mutation (1 available); any Rest mutation (96 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
head spot ( J:230341 )
• in rare cases (2 of 40), mice develop a small white spot on their forehead

integument
head spot ( J:230341 )
• in rare cases (2 of 40), mice develop a small white spot on their forehead




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory