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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chgbtm1Ribo
targeted mutation 1, Ricardo Borges
MGI:4437075
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chgbtm1Ribo/Chgbtm1Ribo involves: 129P2/OlaHsd * C57BL/6 MGI:4456145
hm2
 		Chgbtm1Ribo/Chgbtm1Ribo involves: 129P2/OlaHsd * C57BL/6J MGI:4437076


Genotype
MGI:4456145
hm1
Allelic
Composition		 Chgbtm1Ribo/Chgbtm1Ribo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chgbtm1Ribo mutation (0 available); any Chgb mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal endocrine pancreas physiology ( J:157614 )
• decreased hormone secretion from islets of langerhans in vitro
• granule number and morphology of beta cells are unchanged
decreased insulin secretion ( J:157614 )
• in response to the glucose challenge, the peak in plasma insulin was decreased compared to wild type control

homeostasis/metabolism
decreased insulin secretion ( J:157614 )
• in response to the glucose challenge, the peak in plasma insulin was decreased compared to wild type control
impaired glucose tolerance ( J:157614 )
• plasma glucose level in response to i.p. glucose injection was higher than wild type control
• however, insulin sensitivity was not affected




Genotype
MGI:4437076
hm2
Allelic
Composition		 Chgbtm1Ribo/Chgbtm1Ribo
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chgbtm1Ribo mutation (0 available); any Chgb mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal adrenal chromaffin cell morphology ( J:157697 )
• basal catecholamine levels in chromaffin cells are lower than in wild-type cells
abnormal adrenal gland secretion ( J:157697 )
• evoked catecholamine secretions from chromaffin cell are decreased 33% compared to in wild-type mice
• exocytosis spikes are less than in wild-type cells
• L-DOPA-treated cells fail to uptake more catecholamines unlike similarly treated wild-type cells
• chromaffin cells exhibit a reduction in catecholamine secretion per quantal size of exocytosis compared with wild-type cells
• however, the frequency of exocytotic events is normal

homeostasis/metabolism
decreased adrenaline level ( J:157697 )
• adrenomedullary epinephrine levels are decreased 36% compared to in wild-type mice

nervous system
abnormal adrenal chromaffin cell morphology ( J:157697 )
• basal catecholamine levels in chromaffin cells are lower than in wild-type cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory