Phenotypes associated with this allele

• Allele Symbol: Sertad1^tm1Srn
• Allele Name: targeted mutation 1, Manuel Serrano
• Allele ID: MGI:4437094
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sertad1^tm1Srn/Sertad1^tm1Srn	B6.129-Sertad1^tm1Srn	MGI:4437096
hm2	Sertad1^tm1Srn/Sertad1^tm1Srn	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:4437095

Genotype
MGI:4437096

hm1

• Allelic Composition: Sertad1^tm1Srn/Sertad1^tm1Srn
• Genetic Background: B6.129-Sertad1^tm1Srn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell mass ( J:157231 )

• beta cell volume is decreased 50% compared to in wild-type mice

decreased pancreatic islet number ( J:157231 )

decreased insulin secretion ( J:157231 )

• after injection of glucose

homeostasis/metabolism

decreased insulin secretion ( J:157231 )

• after injection of glucose

impaired glucose tolerance ( J:157231 )

• in a glucose tolerance test and fed a standard or high fat diet, mice exhibit poorer clearance of glucose from blood compared with similarly treated wild-type mice

Genotype
MGI:4437095

hm2

• Allelic Composition: Sertad1^tm1Srn/Sertad1^tm1Srn
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/c

mortality/aging

mortality/aging ( J:157231 )

N • mice exhibit a normal lifespan

cellular

cellular phenotype ( J:157231 )

N • mouse embryonic fibroblasts exhibit normal proliferation, induced apoptosis, immortalization, and oncogenic transformation

neoplasm

neoplasm ( J:157231 )

N • mice exhibit normal spontaneous and induced tumorigenesis