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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Maged1tm1.1Urfm
targeted mutation 1.1, Olivier De Backer
MGI:4437118
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Maged1tm1.1Urfm/Maged1tm1.1Urfm B6.129P2-Maged1tm1.1Urfm MGI:4437119
hm2
 		Maged1tm1.1Urfm/Maged1tm1.1Urfm involves: 129P2/OlaHsd MGI:4437123


Genotype
MGI:4437119
hm1
Allelic
Composition		 Maged1tm1.1Urfm/Maged1tm1.1Urfm
Genetic
Background		 B6.129P2-Maged1tm1.1Urfm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1tm1.1Urfm mutation (0 available); any Maged1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:157604 )
N
• unlike in Ngfr null mice, no defect in neuronal growth is detected
decreased neuron apoptosis ( J:157604 )
• motorneuron apoptosis is sharply reduced
abnormal superior cervical ganglion morphology ( J:157604 )
• between P3 and P23, the number of sympathetic neurons in the NRAGE null animals drops but remains still significantly higher than in wild-type littermates
abnormal sympathetic neuron physiology ( J:157604 )
• the effect of brain-derived neurotrophic factor is significantly reduced, exposure to the ligand causes only a twofold increase in superior cervical ganglia cell death in primary cell culture

integument
abnormal hair cycle catagen phase ( J:157604 )
• profound delay in catagen-dependent dermal thinning, a reduction in the hair follicle bulb volume and hair follicle shortening during the first hair follicle cycle and after depilation

cellular
decreased neuron apoptosis ( J:157604 )
• motorneuron apoptosis is sharply reduced




Genotype
MGI:4437123
hm2
Allelic
Composition		 Maged1tm1.1Urfm/Maged1tm1.1Urfm
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Maged1tm1.1Urfm mutation (0 available); any Maged1 mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
abnormal eye physiology ( J:157549 )
• mice subjected to intraocular injection of the pro form of nerve growth factor are protected from induced retinal ganglion cell death

homeostasis/metabolism
abnormal tumor necrosis factor level ( J:157549 )
• the pro form of nerve growth factor fails to induce TNF expression in retinas

immune system
abnormal tumor necrosis factor level ( J:157549 )
• the pro form of nerve growth factor fails to induce TNF expression in retinas




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory