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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ighmtm1.1(IGH-2)Cog
targeted mutation 1.1, Michel Cogne
MGI:4437126
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4437206
cx2
 		Aicdatm1Hon/Aicdatm1Hon
Ighmtm1.1(IGH-2)Cog/Ighm+ 		involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N MGI:4437207


Genotype
MGI:4437206
hm1
Allelic
Composition		 Ighmtm1.1(IGH-2)Cog/Ighmtm1.1(IGH-2)Cog
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmtm1.1(IGH-2)Cog mutation (0 available); any Ighm mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:157575 )
N
• mice exhibit roughly normal humoral responses
decreased B cell proliferation ( J:157575 )
• LPS-stimulated CD19+ splenocytes exhibit reduced proliferation compared with similarly treated wild-type cells
increased B cell proliferation ( J:157575 )
• BCR-cross-linking stimulated increased proliferation in CD19+ splenocytes compared with similarly treated wild-type cells
abnormal B cell differentiation ( J:157575 )
• mice exhibit a 3-fold reduction in bone marrow B-lineage cells compared with wild-type mice
• mice exhibit a blockage in the transition from large pre-BII (BP1+) to small pre-BII (BP1-) unlike wild-type mice
• B cells are constitutively activated and committed to CD138+ differentiation unlike in wild-type mice
abnormal plasma cell differentiation ( J:157575 )
• immunized mice exhibit increased plasma cell differentiation compared with wild-type mice
• stimulated splenocytes exhibit a bias towards plasma cell differentiation unlike wild-type cells
• however, the ratio of long-lived to short lived plasma cells is normal
decreased pre-B cell number ( J:157575 )
• mice exhibit an 8-fold reduction in the absolute value of CD25+B220+ pre-BII cells compared with wild-type mice
• mice exhibit a reduction in the proportion of CD25+VpreB- cells compared with wild-type mice
increased B cell number ( J:157575 )
• mice exhibit a 3 times increase in VpreB+ cells, which include pro-B/preBI and pre-BII cells, compared with wild-type mice
• mice exhibit an increase in B220+ BCR- cells compared with wild-type mice
increased plasma cell number ( J:157575 )
• immunized mice exhibit a 6-fold increase in plasma cells compared with wild-type mice
decreased IgA level ( J:157575 )
• reduced 10- to 100-fold
decreased IgG level ( J:157575 )
• reduced 10- to 100-fold
decreased Peyer's patch number ( J:157575 )
• Peyer's patches are reduced in number or absent unlike in wild-type mice

hematopoietic system
decreased B cell proliferation ( J:157575 )
• LPS-stimulated CD19+ splenocytes exhibit reduced proliferation compared with similarly treated wild-type cells
increased B cell proliferation ( J:157575 )
• BCR-cross-linking stimulated increased proliferation in CD19+ splenocytes compared with similarly treated wild-type cells
abnormal B cell differentiation ( J:157575 )
• mice exhibit a 3-fold reduction in bone marrow B-lineage cells compared with wild-type mice
• mice exhibit a blockage in the transition from large pre-BII (BP1+) to small pre-BII (BP1-) unlike wild-type mice
• B cells are constitutively activated and committed to CD138+ differentiation unlike in wild-type mice
abnormal plasma cell differentiation ( J:157575 )
• immunized mice exhibit increased plasma cell differentiation compared with wild-type mice
• stimulated splenocytes exhibit a bias towards plasma cell differentiation unlike wild-type cells
• however, the ratio of long-lived to short lived plasma cells is normal
decreased pre-B cell number ( J:157575 )
• mice exhibit an 8-fold reduction in the absolute value of CD25+B220+ pre-BII cells compared with wild-type mice
• mice exhibit a reduction in the proportion of CD25+VpreB- cells compared with wild-type mice
increased B cell number ( J:157575 )
• mice exhibit a 3 times increase in VpreB+ cells, which include pro-B/preBI and pre-BII cells, compared with wild-type mice
• mice exhibit an increase in B220+ BCR- cells compared with wild-type mice
increased plasma cell number ( J:157575 )
• immunized mice exhibit a 6-fold increase in plasma cells compared with wild-type mice
decreased IgA level ( J:157575 )
• reduced 10- to 100-fold
decreased IgG level ( J:157575 )
• reduced 10- to 100-fold

cellular
decreased B cell proliferation ( J:157575 )
• LPS-stimulated CD19+ splenocytes exhibit reduced proliferation compared with similarly treated wild-type cells
increased B cell proliferation ( J:157575 )
• BCR-cross-linking stimulated increased proliferation in CD19+ splenocytes compared with similarly treated wild-type cells




Genotype
MGI:4437207
cx2
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ighmtm1.1(IGH-2)Cog/Ighm+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * CBA * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (57 available)
Ighmtm1.1(IGH-2)Cog mutation (0 available); any Ighm mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:157575 )
• mIgA1+ cells compete poorly for entry into mucosa-associated lymphoid tissues compared with wild-type cells

hematopoietic system
abnormal B cell physiology ( J:157575 )
• mIgA1+ cells compete poorly for entry into mucosa-associated lymphoid tissues compared with wild-type cells




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory