Phenotypes associated with this allele

• Allele Symbol: Setd2^tm1Zhch
• Allele Name: targeted mutation 1, Zhu Chen
• Allele ID: MGI:4437211
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Setd2^tm1Zhch/Setd2^tm1Zhch	involves: 129S1/Sv * C57BL/6	MGI:4437215

Genotype
MGI:4437215

hm1

• Allelic Composition: Setd2^tm1Zhch/Setd2^tm1Zhch
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:157570 )

• there are no viable mice beyond E10.5

embryo

abnormal vitelline vasculature morphology ( J:157570 )

• at E10.5, yolk sacs exhibit poorly organized, dilated primitive capillaries but not large vitelline vessels unlike in wild-type mice

• mice exhibit disorganized vasculature in the yolk sac compared with wild-type mice

pharyngeal arch hypoplasia ( J:157570 )

• at E10.5, branchial arches are underdeveloped compared to in wild-type mice

incomplete embryo turning ( J:157570 )

embryonic growth retardation ( J:157570 )

• from E8.5

open neural tube ( J:157570 )

• at E10.5

abnormal placenta labyrinth morphology ( J:157570 )

• labyrinth thickness is reduced compared to in wild-type mice

• embryonic blood vessels fail to invade the labyrinthine layer

abnormal placental labyrinth vasculature morphology ( J:157570 )

• labyrinthine layer lacks an intricate network of branching embryonic vessels unlike in wild-type mice

abnormal visceral yolk sac morphology ( J:157570 )

• yolk sacs contain increased cavities compared to in wild-type mice

• fewer attachments between visceral endoderm and mesoderm are observed compared to in wild-type

abnormal visceral yolk sac mesenchyme morphology ( J:157570 )

• mesoderm cells in the yolk sac are abnormally rounded

failure of chorioallantoic fusion ( J:157570 )

cardiovascular system

abnormal blood vessel morphology ( J:157570 )

• at E10.5, mice exhibit disorganized and dilated veins and capillaries unlike in wild-type mice

• at E10.5, mice do not exhibit intricate networks of vessels instead abnormally dilated and irregularly shaped blood vessels, especially in the head region, unlike wild-type mice

abnormal placental labyrinth vasculature morphology ( J:157570 )

• labyrinthine layer lacks an intricate network of branching embryonic vessels unlike in wild-type mice

abnormal vitelline vasculature morphology ( J:157570 )

• at E10.5, yolk sacs exhibit poorly organized, dilated primitive capillaries but not large vitelline vessels unlike in wild-type mice

• mice exhibit disorganized vasculature in the yolk sac compared with wild-type mice

blood vessel congestion ( J:157570 )

• in the head

pericardial effusion ( J:157570 )

• frequently observed

craniofacial

pharyngeal arch hypoplasia ( J:157570 )

• at E10.5, branchial arches are underdeveloped compared to in wild-type mice

growth/size/body

embryonic growth retardation ( J:157570 )

• from E8.5

abnormal head development ( J:157570 )

• at E10.5, mice exhibit underdeveloped heads unlike wild-type mice

homeostasis/metabolism

pericardial effusion ( J:157570 )

• frequently observed

edema ( J:157570 )

• at E10.5, head edema in unilateral or bilateral headfolds

nervous system

open neural tube ( J:157570 )

• at E10.5

forebrain hypoplasia ( J:157570 )

• at E10.5