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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgf8tm2.1Jyhl
targeted mutation 2.1, James Y H Li
MGI:4437219
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl B6.129S6-Fgf8tm2.1Jyhl MGI:4437227
hm2
 		Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl involves: 129S6/SvEvTac * CD-1 MGI:4437224
ht3
 		Fgf8tm2.1Jyhl/Fgf8+ B6.129S6-Fgf8tm2.1Jyhl MGI:4437226
cn4
 		En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl
Gt(ROSA)26Sortm1Sor/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:4437229


Genotype
MGI:4437227
hm1
Allelic
Composition		 Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
Genetic
Background		 B6.129S6-Fgf8tm2.1Jyhl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:156717 )
• very few were recovered
• Background Sensitivity: lethality is more severe on a C57BL/6J inbred background compared to a CD-1 outbred background




Genotype
MGI:4437224
hm2
Allelic
Composition		 Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
Genetic
Background		 involves: 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:156717 )
• some pups are found dead before weaning
• Background Sensitivity: lethality is less severe on a CD-1 outbred background compared to a C57BL/6J inbred background

growth/size/body
decreased body weight ( J:156717 )
• average body weight is significantly lower at E18.5 and postnatal day 24

nervous system
nervous system phenotype ( J:156717 )
N
• unlike in mice lacking all isoforms of Fgf8, midbrain and cerebellum formation are normal




Genotype
MGI:4437226
ht3
Allelic
Composition		 Fgf8tm2.1Jyhl/Fgf8+
Genetic
Background		 B6.129S6-Fgf8tm2.1Jyhl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:156717 )
N
• Background Sensitivity: fewer than expected are found at weaning unlike when mice are on a CD-1 outbred background

growth/size/body
decreased body weight ( J:156717 )
• mice tend to have a lower body weight




Genotype
MGI:4437229
cn4
Allelic
Composition		 En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl
Gt(ROSA)26Sortm1Sor/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm7(cre/ESR1)Alj mutation (1 available); any En1 mutation (34 available)
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:156717 )
N
• unlike mice homozygous for Fgf8tm2.1Jyhl, mice are normal in size

nervous system
nervous system phenotype ( J:156717 )
N
• unlike mice homozygous for Fgf8tm2.1Jyhl, the size of the midbrain and cerebellum are normal




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory