About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fgf8tm2.1Jyhl
targeted mutation 2.1, James Y H Li
MGI:4437219
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl B6.129S6-Fgf8tm2.1Jyhl MGI:4437227
hm2
 		Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl involves: 129S6/SvEvTac * CD-1 MGI:4437224
ht3
 		Fgf8tm2.1Jyhl/Fgf8+ B6.129S6-Fgf8tm2.1Jyhl MGI:4437226
cn4
 		En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl
Gt(ROSA)26Sortm1Sor/0 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:4437229


Genotype
MGI:4437227
hm1
Allelic
Composition		 Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
Genetic
Background		 B6.129S6-Fgf8tm2.1Jyhl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:156717 )
• very few were recovered
• Background Sensitivity: lethality is more severe on a C57BL/6J inbred background compared to a CD-1 outbred background




Genotype
MGI:4437224
hm2
Allelic
Composition		 Fgf8tm2.1Jyhl/Fgf8tm2.1Jyhl
Genetic
Background		 involves: 129S6/SvEvTac * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality ( J:156717 )
• some pups are found dead before weaning
• Background Sensitivity: lethality is less severe on a CD-1 outbred background compared to a C57BL/6J inbred background

growth/size/body
decreased body weight ( J:156717 )
• average body weight is significantly lower at E18.5 and postnatal day 24

nervous system
nervous system phenotype ( J:156717 )
N
• unlike in mice lacking all isoforms of Fgf8, midbrain and cerebellum formation are normal




Genotype
MGI:4437226
ht3
Allelic
Composition		 Fgf8tm2.1Jyhl/Fgf8+
Genetic
Background		 B6.129S6-Fgf8tm2.1Jyhl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:156717 )
N
• Background Sensitivity: fewer than expected are found at weaning unlike when mice are on a CD-1 outbred background

growth/size/body
decreased body weight ( J:156717 )
• mice tend to have a lower body weight




Genotype
MGI:4437229
cn4
Allelic
Composition		 En1tm7(cre/ESR1)Alj/0
Fgf8tm1.3Mrt/Fgf8tm2.1Jyhl
Gt(ROSA)26Sortm1Sor/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm7(cre/ESR1)Alj mutation (1 available); any En1 mutation (34 available)
Fgf8tm1.3Mrt mutation (1 available); any Fgf8 mutation (21 available)
Fgf8tm2.1Jyhl mutation (0 available); any Fgf8 mutation (21 available)
Gt(ROSA)26Sortm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:156717 )
N
• unlike mice homozygous for Fgf8tm2.1Jyhl, mice are normal in size

nervous system
nervous system phenotype ( J:156717 )
N
• unlike mice homozygous for Fgf8tm2.1Jyhl, the size of the midbrain and cerebellum are normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory