Phenotypes associated with this allele

• Allele Symbol: Chrm1^tm2.1Stl
• Allele Name: targeted mutation 2.1, Susumu Tonegawa
• Allele ID: MGI:4437231
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Chrm1^tm2.1Stl/Chrm1^tm2.1Stl Emx1^tm1.1(cre)Ito/0	involves: 129P2/OlaHsd	MGI:4437232
cn2	Chrm1^tm2.1Stl/Chrm1^tm2.1Stl Tg(Grik4-cre)G32-4Stl/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4437233

Genotype
MGI:4437232

cn1

• Allelic Composition: Chrm1^tm2.1Stl/Chrm1^tm2.1Stl; Emx1^{tm1.1(cre)Ito}/0
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic currents ( J:156540 )

• baseline excitatory postsynaptic currents from hippocampal slices are higher than in wild-type

abnormal miniature excitatory postsynaptic currents ( J:156540 )

• the frequency of events is significantly higher in miniature excitatory postsynaptic currents (minis) from CA1 pyramidal neurons

abnormal long-term depression ( J:156540 )

• (S)-3,5-dihydroxyphenylglycine hydrate (DHPG), an mGluR agonist, fails to produce long-term depression in hippocampal slices

decreased paired-pulse facilitation ( J:156540 )

• decrease in degree of facilitation of the second response in a paired-pulse

Genotype
MGI:4437233

cn2

• Allelic Composition: Chrm1^tm2.1Stl/Chrm1^tm2.1Stl; Tg(Grik4-cre)G32-4Stl/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

nervous system

abnormal excitatory postsynaptic currents ( J:156540 )

• excitatory postsynaptic currents from hippocampal slices are higher than in wild-type

abnormal long-term depression ( J:156540 )

• (S)-3,5-dihydroxyphenylglycine hydrate (DHPG), an mGluR agonist, fails to produce long-term depression in hippocampal slices

• pretreatment of hippocampal slices with PKC activator 12-O-tetradecanoylphorbol 13-acetate, restores DHPG long-term

decreased paired-pulse facilitation ( J:156540 )