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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ext1tm1.2Vcs
targeted mutation 1.2, Val C Sheffield
MGI:4437237
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ext1tm1.2Vcs/Ext1tm1.2Vcs involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4437600
ht2
 		Ext1tm1.2Vcs/Ext1+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4437601


Genotype
MGI:4437600
hm1
Allelic
Composition		 Ext1tm1.2Vcs/Ext1tm1.2Vcs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1.2Vcs mutation (0 available); any Ext1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

embryo
failure to gastrulate ( J:157599 )
• embryos have failed to undergo gastrulation when examined at E7.0
decreased embryo size ( J:157599 )
• embryos are small compared to littermate controls at E7.0

growth/size/body
decreased embryo size ( J:157599 )
• embryos are small compared to littermate controls at E7.0




Genotype
MGI:4437601
ht2
Allelic
Composition		 Ext1tm1.2Vcs/Ext1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1.2Vcs mutation (0 available); any Ext1 mutation (65 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:157599 )
N
• pups are born at normal Mendelian ratios




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory