Phenotypes associated with this allele

• Allele Symbol: Dhx58^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:4437255
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhx58^tm1Aki/Dhx58^tm1Aki	involves: 129/Sv * C57BL/6	MGI:4437258

Genotype
MGI:4437258

hm1

• Allelic Composition: Dhx58^tm1Aki/Dhx58^tm1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:156867 )

• following infection with encephalomyocarditis virus, mice die earlier than wild-type mice

prenatal lethality, incomplete penetrance ( J:156867 )

• fewer than expected homozygotes, no time of lethality provided

reproductive system

enlarged uterus ( J:156867 )

♀ • filled with fluid

vagina atresia ( J:156867 )

♀

immune system

decreased circulating interferon-beta level ( J:156867 )

• undetectable in sera from mice challenged with encephalomyocarditis virus

decreased interferon-beta secretion ( J:156867 )

• impairment in RNA virus induced production in conventional dendritic cells however response to influenza virus is normal

decreased interleukin-6 secretion ( J:156867 )

• IL-6 production induced by encephalomyocarditis virus infection is severely impaired

increased susceptibility to Picornaviridae infection ( J:156867 )

• following infection with encephalomyocarditis virus, the viral titer in the heart is remarkably higher than that in wild-type mice

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:156867 )

• following infection with encephalomyocarditis virus, mice die earlier than wild-type mice

homeostasis/metabolism

decreased circulating interferon-beta level ( J:156867 )

• undetectable in sera from mice challenged with encephalomyocarditis virus