Phenotypes associated with this allele

• Allele Symbol: Dhx58^tm2.1Aki
• Allele Name: targeted mutation 2.1, Shizuo Akira
• Allele ID: MGI:4437256
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dhx58^tm2.1Aki/Dhx58^tm2.1Aki	involves: 129/Sv * C57BL/6	MGI:4437259

Genotype
MGI:4437259

hm1

• Allelic Composition: Dhx58^tm2.1Aki/Dhx58^tm2.1Aki
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:156867 )

• with encephalomyocarditis virus mice die earlier than wild-type mice

immune system

decreased interferon-beta secretion ( J:156867 )

• severe impairment in RNA virus induced production in conventional dendritic cells however response to influenza virus is normal

decreased interleukin-6 secretion ( J:156867 )

• IL-6 production induced by encephalomyocarditis virus infection is severely impaired

increased susceptibility to Picornaviridae infection ( J:156867 )

• with encephalomyocarditis virus there are highly increased viral titers in their hearts

increased susceptibility to Picornaviridae infection induced morbidity/mortality ( J:156867 )

• with encephalomyocarditis virus mice die earlier than wild-type mice