About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nod2tm1Daph
targeted mutation 1, Dana Philpott
MGI:4437257
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nod2tm1Daph/Nod2tm1Daph involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4437263


Genotype
MGI:4437263
hm1
Allelic
Composition		 Nod2tm1Daph/Nod2tm1Daph
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nod2tm1Daph mutation (0 available); any Nod2 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagy ( J:157879 )
• fewer LC3+ bacteria are observed in GFP-LC3-transdeuced bone marrow-derived macrophages infected with S. flexneri compared to in similarly treated wild-type mice

immune system
abnormal macrophage physiology ( J:157879 )
• muramyl dipeptide (MDP)-stimulated bone marrow-derived macrophages do not secrete CXCL1(KC) unlike similarly treated wild-type cells

hematopoietic system
abnormal macrophage physiology ( J:157879 )
• muramyl dipeptide (MDP)-stimulated bone marrow-derived macrophages do not secrete CXCL1(KC) unlike similarly treated wild-type cells

homeostasis/metabolism
abnormal autophagy ( J:157879 )
• fewer LC3+ bacteria are observed in GFP-LC3-transdeuced bone marrow-derived macrophages infected with S. flexneri compared to in similarly treated wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory