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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nod2tm1Daph
targeted mutation 1, Dana Philpott
MGI:4437257
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nod2tm1Daph/Nod2tm1Daph involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4437263


Genotype
MGI:4437263
hm1
Allelic
Composition		 Nod2tm1Daph/Nod2tm1Daph
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nod2tm1Daph mutation (0 available); any Nod2 mutation (63 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagy ( J:157879 )
• fewer LC3+ bacteria are observed in GFP-LC3-transdeuced bone marrow-derived macrophages infected with S. flexneri compared to in similarly treated wild-type mice

immune system
abnormal macrophage physiology ( J:157879 )
• muramyl dipeptide (MDP)-stimulated bone marrow-derived macrophages do not secrete CXCL1(KC) unlike similarly treated wild-type cells

hematopoietic system
abnormal macrophage physiology ( J:157879 )
• muramyl dipeptide (MDP)-stimulated bone marrow-derived macrophages do not secrete CXCL1(KC) unlike similarly treated wild-type cells

homeostasis/metabolism
abnormal autophagy ( J:157879 )
• fewer LC3+ bacteria are observed in GFP-LC3-transdeuced bone marrow-derived macrophages infected with S. flexneri compared to in similarly treated wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory