Phenotypes associated with this allele

• Allele Symbol: Nfatc2ip^tm1.1Glm
• Allele Name: targeted mutation 1.1, Laurie Glimcher
• Allele ID: MGI:4437260
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nfatc2ip^tm1.1Glm/Nfatc2ip^tm1.1Glm	either: B6.129-Nfatc2ip^tm1.1Glm or C.129-Nfatc2ip^tm1.1Glm	MGI:4437262

Genotype
MGI:4437262

hm1

• Allelic Composition: Nfatc2ip^tm1.1Glm/Nfatc2ip^tm1.1Glm
• Genetic Background: either: B6.129-Nfatc2ip^tm1.1Glm or C.129-Nfatc2ip^tm1.1Glm

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in mast cells in the jejunum of T. spiralis-infected Nfatc2ip^tm1.1Glm/Nfatc2ip^tm1.1Glm mice

immune system

abnormal leukocyte morphology ( J:157559 )

decreased mast cell number ( J:157559 )

• decreased jejunal mastocytosis after infection with T.spiralis larvae

• however, the number of mast cells in uninfected mice is not different from wild-type

decreased T-helper 2 cell number ( J:157559 )

abnormal T-helper 2 physiology ( J:157559 )

• impairment in IL-4 and IL-13 responses in anti-CD3 stimulated mesenteric T helper cells from T.spiralis infected mice

decreased circulating interleukin-4 level ( J:157559 )

• after infection with T.spiralis larvae, serum IL4 levels are reduced 4-fold

decreased interferon-gamma secretion ( J:157559 )

• in nave T helper cells cultured in Th1 polarizing conditions for 7 days and stimulated with plate-bound anti-CD3 for 24 hours

abnormal interleukin secretion ( J:157559 )

decreased interleukin-13 secretion ( J:157559 )

• after anti-CD3 stimulation of mesenteric T helper cells from T.spiralis infected mice

decreased interleukin-3 secretion ( J:157559 )

• mesenteric T helper display significantly impaired IL3 production

decreased interleukin-4 secretion ( J:157559 )

• after anti-CD3 stimulation of mesenteric T helper cells from T.spiralis infected mice

• reduction in IL4 production by in vitro derived Th2 cells

decreased interleukin-5 secretion ( J:157559 )

• IL5 production by in vitro derived Th2 cells is reduced

increased susceptibility to parasitic infection ( J:157559 )

• an elevated intestinal worm burden after T. spiralis infection

homeostasis/metabolism

decreased circulating interleukin-4 level ( J:157559 )

• after infection with T.spiralis larvae, serum IL4 levels are reduced 4-fold

hematopoietic system

abnormal leukocyte morphology ( J:157559 )

decreased mast cell number ( J:157559 )

• decreased jejunal mastocytosis after infection with T.spiralis larvae

• however, the number of mast cells in uninfected mice is not different from wild-type

decreased T-helper 2 cell number ( J:157559 )

abnormal T-helper 2 physiology ( J:157559 )

• impairment in IL-4 and IL-13 responses in anti-CD3 stimulated mesenteric T helper cells from T.spiralis infected mice