mortality/aging
• mice die at E12.5 from central nervous system hemorrhage
|
hematopoietic system
• E12.5 liver cells fail to form colonies in a methocellulose colony forming unit assay unlike wild-type cells
|
• at E12.5, livers lack hematopoietic precursor/progenitor cells unlike in wild-type mice
|
liver/biliary system
pale liver
(
J:157660
)
• at E12.5
|
cardiovascular system
hemorrhage
(
J:157660
)
• at E12.5, mice exhibit variable patterns of hemorrhage including in the central nervous system unlike wild-type mice
|