Phenotypes associated with this allele

• Allele Symbol: Ptk2^tm1Heen
• Allele Name: targeted mutation 1, Herve Enslen
• Allele ID: MGI:4437305
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ptk2^tm1Heen/Ptk2^tm1Heen	involves: 129/Sv * C57BL/6	MGI:4437306

Genotype
MGI:4437306

hm1

• Allelic Composition: Ptk2^tm1Heen/Ptk2^tm1Heen
• Genetic Background: involves: 129/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Hemorrhages, edemas, abnormal heart, lung, liver and limb development, and delayed artery formation and vascular remodeling defects in Ptk2^tm1Heen/Ptk2^tm1Heen embryos

mortality/aging

decreased survivor rate ( J:157804 )

• unlike null homozygotes, rare mice do survive into adulthood

lethality throughout fetal growth and development, incomplete penetrance ( J:157804 )

• few mice survive past E16.5

embryonic lethality during organogenesis, incomplete penetrance ( J:157804 )

• some mice die between E11.5 and E14.5

reproductive system

reproductive system phenotype ( J:157804 )

N • rare mice that do survive into adulthood are fertile

cardiovascular system

abnormal blood vessel morphology ( J:157804 )

• at E13.5, superficial vasculature is abnormal compared with wild-type mice

abnormal vitelline vasculature morphology ( J:157804 )

• at E14.5

disorganized yolk sac vascular plexus ( J:157804 )

abnormal heart development ( J:157804 )

• at E14.5, mice exhibit altered and retarded heart development compared with wild-type mice

delayed heart development ( J:157804 )

hemorrhage ( J:157804 )

• at E13.5, mice exhibit hemorrhagic livers and multiple body hemorrhages unlike wild-type mice

liver hemorrhage ( J:157804 )

• at E13.5

embryo

abnormal vitelline vasculature morphology ( J:157804 )

• at E14.5

disorganized yolk sac vascular plexus ( J:157804 )

embryonic growth retardation ( J:157804 )

• at E13.5

decreased embryo size ( J:157804 )

• at E13.5

growth/size/body

embryonic growth retardation ( J:157804 )

• at E13.5

decreased embryo size ( J:157804 )

• at E13.5

cellular

decreased fibroblast cell migration ( J:157804 )

• fibroblasts on polylysine or fibronectin exhibit delayed spreading compared with wild-type cells

decreased fibroblast proliferation ( J:157804 )

• in mouse embryonic fibroblasts

homeostasis/metabolism

edema ( J:157804 )

• at E13.5

limbs/digits/tail

abnormal limb development ( J:157804 )

• at E14.5, mice exhibit altered and retarded limb development compared with wild-type mice

liver/biliary system

liver hemorrhage ( J:157804 )

• at E13.5

abnormal liver development ( J:157804 )

• at E14.5, mice exhibit altered and retarded liver development compared with wild-type mice

delayed hepatic development ( J:157804 )

respiratory system

abnormal lung development ( J:157804 )

• at E14.5, mice exhibit altered and retarded lung development compared with wild-type mice