About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il10ratm1.1Jack
targeted mutation 1.1, Robert S Jack
MGI:4437317
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Scn10atm2(cre)Jwo/Scn10a+
Il10ratm1.1Jack/Il10ratm1.1Jack 		involves: 129P2/OlaHsd MGI:7334745
cn2
 		Il10ratm1.1Jack/Il10ratm1.1Jack
Lyz2tm1(cre)Ifo/Lyz2+ 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:4437328
cn3
 		Cd19tm1(cre)Cgn/Cd19+
Il10ratm1.1Jack/Il10ratm1.1Jack 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 MGI:4437331
cn4
 		Il10ratm1.1Jack/Il10ratm1.1Jack
Tg(Cd4-cre)1Cwi/0 		involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2 MGI:4437330


Genotype
MGI:7334745
cn1
Allelic
Composition		 Scn10atm2(cre)Jwo/Scn10a+
Il10ratm1.1Jack/Il10ratm1.1Jack
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10ratm1.1Jack mutation (1 available); any Il10ra mutation (32 available)
Scn10atm2(cre)Jwo mutation (3 available); any Scn10a mutation (102 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:326965 )
N
• mice exhibit normal recovery from carrageenan-induced inflammatory hyperalgesia




Genotype
MGI:4437328
cn2
Allelic
Composition		 Il10ratm1.1Jack/Il10ratm1.1Jack
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10ratm1.1Jack mutation (1 available); any Il10ra mutation (32 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (40 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal cytokine level ( J:157787 )
• in LPS-injected mice
increased circulating interferon-gamma level ( J:157787 )
• in LPS-injected mice compared with similarly treated wild-type mice
increased circulating interleukin-12 level ( J:157787 )
• in LPS-injected mice compared with similarly treated Il10ratm1.1Jack homozygotes
increased circulating tumor necrosis factor level ( J:157787 )
• in LPS-injected mice compared with similarly treated Il10ratm1.1Jack homozygotes
abnormal chemokine level ( J:157787 )
• LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice
increased susceptibility to parasitic infection ( J:157787 )
• mice infected with T. muris exhibit increased cecum score compared with similarly treated wild-type mice

homeostasis/metabolism
abnormal cytokine level ( J:157787 )
• in LPS-injected mice
increased circulating interferon-gamma level ( J:157787 )
• in LPS-injected mice compared with similarly treated wild-type mice
increased circulating interleukin-12 level ( J:157787 )
• in LPS-injected mice compared with similarly treated Il10ratm1.1Jack homozygotes
increased circulating tumor necrosis factor level ( J:157787 )
• in LPS-injected mice compared with similarly treated Il10ratm1.1Jack homozygotes
abnormal chemokine level ( J:157787 )
• LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice




Genotype
MGI:4437331
cn3
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Il10ratm1.1Jack/Il10ratm1.1Jack
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (11 available); any Cd19 mutation (60 available)
Il10ratm1.1Jack mutation (1 available); any Il10ra mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:157787 )
N
• mice exhibit a normal response to LPS injection and T. muris infection




Genotype
MGI:4437330
cn4
Allelic
Composition		 Il10ratm1.1Jack/Il10ratm1.1Jack
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il10ratm1.1Jack mutation (1 available); any Il10ra mutation (32 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:157787 )
N
• mice exhibit a normal response to LPS injection and T. muris infection




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory