Phenotypes associated with this allele

• Allele Symbol: Il10ra^tm1.2Jack
• Allele Name: targeted mutation 1.2, Robert S Jack
• Allele ID: MGI:4437318
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Il10ra^tm1.2Jack/Il10ra^tm1.2Jack	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2	MGI:4437329

Genotype
MGI:4437329

hm1

• Allelic Composition: Il10ra^tm1.2Jack/Il10ra^tm1.2Jack
• Genetic Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to induced colitis ( J:157787 )

• upon DSS exposure, mice exhibit increased colitis compared with similarly treated wild-type mice

cecum inflammation ( J:157787 )

• mice infected with T. muris exhibit increased worm burden and cecum score compared with similarly treated wild-type mice

• at P21, T. muris-infected mice exhibit decreased cecum score compared with Il10^tm1Cgn

abnormal cytokine level ( J:157787 )

• in LPS-injected mice

increased circulating interferon-gamma level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-1 alpha level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-1 beta level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-12 level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-17 level ( J:157787 )

• in LPS-injected mice compared with similarly treated wild-type mice and Il10^tm1Cgn homozygotes

increased circulating interleukin-2 level ( J:157787 )

• in LPS-injected mice compared with similarly treated wild-type mice and Il10^tm1Cgn homozygotes

increased circulating interleukin-6 level ( J:157787 )

• slightly in LPS-injected mice

increased circulating tumor necrosis factor level ( J:157787 )

• in LPS-injected mice

abnormal chemokine level ( J:157787 )

• LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice and Il10^tm1Cgn homozygotes

increased susceptibility to parasitic infection ( J:157787 )

• mice infected with T. muris exhibit increased worm burden and cecum score compared with similarly treated wild-type mice

• at P21, T. muris-infected mice exhibit decreased cecum score compared with Il10^tm1Cgn homozygotes

homeostasis/metabolism

abnormal cytokine level ( J:157787 )

• in LPS-injected mice

increased circulating interferon-gamma level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-1 alpha level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-1 beta level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-12 level ( J:157787 )

• in LPS-injected mice

increased circulating interleukin-17 level ( J:157787 )

• in LPS-injected mice compared with similarly treated wild-type mice and Il10^tm1Cgn homozygotes

increased circulating interleukin-2 level ( J:157787 )

• in LPS-injected mice compared with similarly treated wild-type mice and Il10^tm1Cgn homozygotes

increased circulating interleukin-6 level ( J:157787 )

• slightly in LPS-injected mice

increased circulating tumor necrosis factor level ( J:157787 )

• in LPS-injected mice

abnormal chemokine level ( J:157787 )

• LPS-injected mice exhibit increased CXCL10 and CXCL1 levels compared with similarly treated wild-type mice and Il10^tm1Cgn homozygotes

digestive/alimentary system

increased susceptibility to induced colitis ( J:157787 )

• upon DSS exposure, mice exhibit increased colitis compared with similarly treated wild-type mice

cecum inflammation ( J:157787 )

• mice infected with T. muris exhibit increased worm burden and cecum score compared with similarly treated wild-type mice

• at P21, T. muris-infected mice exhibit decreased cecum score compared with Il10^tm1Cgn