nervous system
N |
• mice exhibit normal neuronal survival
|
• at 12 months, evoked dopamine release is 35% lower than in wild-type mice
• however, evoked dopamine release at 6 months is normal
|
• at 12 months, dopmine uptake is slower than in wild-type mice
|
behavior/neurological
• at 12 months, mice exhibit less diagonal distance between front and hind limbs than Tg(Lrrk2)6Yue mice
|
• compared with Tg(Lrrk2)6Yue mice at 12 months
|
homeostasis/metabolism
• at 12 months, striatal dopamine levels are 25% lower than in wild-type mice
• however, striatal dopamine levels at 6 months are normal
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Parkinson's disease 8 | DOID:0060371 |
OMIM:607060 |
J:157931 |