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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lrrk2*G2019S)2Yue
transgene insertion 2, Zhenyu Yue
MGI:4437428
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Lrrk2*G2019S)2Yue/0 involves: C3H * C57BL/6 * C57BL/6J MGI:4437437


Genotype
MGI:4437437
tg1
Allelic
Composition
Tg(Lrrk2*G2019S)2Yue/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lrrk2*G2019S)2Yue mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal neuronal survival
• at 12 months, evoked dopamine release is 35% lower than in wild-type mice
• however, evoked dopamine release at 6 months is normal
• at 12 months, dopmine uptake is slower than in wild-type mice

behavior/neurological
• at 12 months, mice exhibit less diagonal distance between front and hind limbs than Tg(Lrrk2)6Yue mice
• compared with Tg(Lrrk2)6Yue mice at 12 months

homeostasis/metabolism
• at 12 months, striatal dopamine levels are 25% lower than in wild-type mice
• however, striatal dopamine levels at 6 months are normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 8 DOID:0060371 OMIM:607060
J:157931





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last database update
11/19/2024
MGI 6.24
The Jackson Laboratory