About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Lrrk2*G2019S)2Yue
transgene insertion 2, Zhenyu Yue
MGI:4437428
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Lrrk2*G2019S)2Yue/0 involves: C3H * C57BL/6 * C57BL/6J MGI:4437437


Genotype
MGI:4437437
tg1
Allelic
Composition
Tg(Lrrk2*G2019S)2Yue/0
Genetic
Background
involves: C3H * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lrrk2*G2019S)2Yue mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal neuronal survival
• at 12 months, evoked dopamine release is 35% lower than in wild-type mice
• however, evoked dopamine release at 6 months is normal
• at 12 months, dopmine uptake is slower than in wild-type mice

behavior/neurological
• at 12 months, mice exhibit less diagonal distance between front and hind limbs than Tg(Lrrk2)6Yue mice
• compared with Tg(Lrrk2)6Yue mice at 12 months

homeostasis/metabolism
• at 12 months, striatal dopamine levels are 25% lower than in wild-type mice
• however, striatal dopamine levels at 6 months are normal

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Parkinson's disease 8 DOID:0060371 OMIM:607060
J:157931





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
10/29/2024
MGI 6.24
The Jackson Laboratory