Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Cast)1Gwd
• Allele Name: transgene insertion 1, Gerald W Dorn II
• Allele ID: MGI:4437429
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Cast)1Gwd/0	involves: FVB/N	MGI:4437450

Genotype
MGI:4437450

tg1

• Allelic Composition: Tg(Myh6-Cast)1Gwd/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:133797 )

• myocytes are variable in size with frequent intracellular inclusions and increased cardiomyocyte cross-sectional area compared to in wild-type mice

abnormal heart left ventricle morphology ( J:133797 )

• following neonatal induction with doxycycline, mice exhibit increased left ventricular end-diastolic and end-systolic dimension compared with wild-type mice

dilated cardiomyopathy ( J:133797 )

• slowly progressive

decreased heart ventricle muscle contractility ( J:133797 )

• ventricular ejection is decreased compared to in wild-type mice

decreased heart left ventricle muscle contractility ( J:133797 )

• in response to dobutamine, the peak rate of change of left ventricular pressure increase is less than in similarly treated wild-type mice

abnormal heart rate ( J:133797 )

• 50% of mice exhibit atrial arrhythmia unlike wild-type mice

decreased heart rate ( J:133797 )

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:133797 )

• in response to dobutamine, the peak rate of change of left ventricular pressure increase is less than in similarly treated wild-type mice

muscle

abnormal myocardial fiber morphology ( J:133797 )

• myocytes are variable in size with frequent intracellular inclusions and increased cardiomyocyte cross-sectional area compared to in wild-type mice

dilated cardiomyopathy ( J:133797 )

• slowly progressive

decreased heart ventricle muscle contractility ( J:133797 )

• ventricular ejection is decreased compared to in wild-type mice

decreased heart left ventricle muscle contractility ( J:133797 )

• in response to dobutamine, the peak rate of change of left ventricular pressure increase is less than in similarly treated wild-type mice