Phenotypes associated with this allele

• Allele Symbol: Mid1^tm1Mero
• Allele Name: targeted mutation 1, Germana Meroni
• Allele ID: MGI:4437430
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	Mid1^tm1Mero/Y	B6.Cg-Mid1^tm1Mero	MGI:4437568

Genotype
MGI:4437568

ot1

• Allelic Composition: Mid1^tm1Mero/Y
• Genetic Background: B6.Cg-Mid1^tm1Mero

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal brain morphology ( J:157828 )

♂ • more rostral boundary between the inferior colliculus and the cerebellum at E17.5

abnormal brain development ( J:157828 )

♂

abnormal cerebellum external granule cell layer morphology ( J:157828 )

♂ • upturning of the external granule layer in the most anterior part of the anterobasal cardinal lobe

♂ • premature halt of the anterior EGL

abnormal midbrain development ( J:157828 )

♂

abnormal midbrain-hindbrain boundary morphology ( J:157828 )

♂ • slightly enlarged isthmic region at E17.5

abnormal midbrain-hindbrain boundary development ( J:157828 )

♂ • more anterior position of dorsal boundary

abnormal tectum morphology ( J:157828 )

♂ • Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum

decreased inferior colliculus size ( J:157828 )

♂ • shorter with the difference in size more pronounced in lateral sections of the vermis at E14.5

abnormal cerebellar cortex morphology ( J:157828 )

♂

ectopic Purkinje cell ( J:157828 )

♂ • Purkinje cells are present in ectopic position within the isthmic region heading toward the tectum

abnormal cerebellum fissure morphology ( J:157828 )

♂ • more profound fissure delimiting future lobes II and III

abnormal cerebellum lobule morphology ( J:157828 )

♂

abnormal cerebellar lobule formation ( J:157828 )

♂ • anterobasal cardinal lobe, appears abnormal at P0 and P2

abnormal cerebellum vermis lobule I morphology ( J:157828 )

♂ • totally missing

abnormal cerebellum vermis lobule II morphology ( J:157828 )

♂ • hypoplasia and abnormalities with a certain degree of variability

abnormal cerebellum vermis lobule III morphology ( J:157828 )

♂ • hypoplasia and abnormalities with a certain degree of variability and abnormality in shape

behavior/neurological

abnormal learning/memory/conditioning ( J:157828 )

♂ • the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice

♂ • record fewer correct responses in the egocentric spatial version of the cross maze task on the fourth training day

♂ • however, performance in an allocentric version of the maze is not significantly different from controls

abnormal motor learning ( J:157828 )

♂ • delay in learning in a rotarod assay

increased startle reflex ( J:157828 )

♂ • the percentage of mean startle amplitude does not significantly decrease from day 1 to day 3 as it does in wild-type mice

impaired coordination ( J:157828 )

♂ • impaired ability to hang on a wire

impaired limb coordination ( J:157828 )

♂ • make more false steps walking on an inclined wire

hyperactivity ( J:157828 )

♂

muscle

muscle phenotype ( J:157828 )

♂N • no defects in muscle function are detected

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Opitz GBBB syndrome		DOID:0080697	OMIM:300000	J:157828