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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Myh6*/tetO-Capn1)L3Gwd
transgene insertion L3, Gerald W Dorn II
MGI:4437470
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Myh6*/tetO-Capn1)L3Gwd/0 involves: FVB/N MGI:4437576


Genotype
MGI:4437576
tg1
Allelic
Composition
Tg(Myh6*/tetO-Capn1)L3Gwd/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
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phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when treated with doxycycline during the first week of life, mice die within the first 2 weeks of life unlike similarly treated Tg(Myh6*/tetO-Capn1)L1Gwd
• when treated with doxycycline at 8 weeks of age, most mice die within 4 weeks unlike similarly treated Tg(Myh6*/tetO-Capn1)L1Gwd

cardiovascular system
• when treated with doxycycline at 8 weeks of age
• at 12 weeks and further at 20 weeks when treated with doxycycline at 8 weeks of age
• following neonatal induction with doxycycline, mice exhibit increased left ventricular end-systolic dimension compared with wild-type mice
• when treated with doxycycline at 8 weeks of age
• following neonatal induction with doxycycline
• when treated with doxycycline at 8 weeks of age
• following neonatal induction with doxycycline, mice exhibit generalized mononuclear cell infiltrate unlike wild-type mice

immune system
• following neonatal induction with doxycycline, mice exhibit generalized mononuclear cell infiltrate unlike wild-type mice

muscle
• when treated with doxycycline at 8 weeks of age
• following neonatal induction with doxycycline

growth/size/body
• at 12 weeks and further at 20 weeks when treated with doxycycline at 8 weeks of age





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory