mortality/aging
• when treated with doxycycline during the first week of life, mice die within the first 2 weeks of life unlike similarly treated Tg(Myh6*/tetO-Capn1)L1Gwd
• when treated with doxycycline at 8 weeks of age, most mice die within 4 weeks unlike similarly treated Tg(Myh6*/tetO-Capn1)L1Gwd
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cardiovascular system
• when treated with doxycycline at 8 weeks of age
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• at 12 weeks and further at 20 weeks when treated with doxycycline at 8 weeks of age
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• following neonatal induction with doxycycline, mice exhibit increased left ventricular end-systolic dimension compared with wild-type mice
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• when treated with doxycycline at 8 weeks of age
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• following neonatal induction with doxycycline
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• when treated with doxycycline at 8 weeks of age
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• following neonatal induction with doxycycline, mice exhibit generalized mononuclear cell infiltrate unlike wild-type mice
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immune system
• following neonatal induction with doxycycline, mice exhibit generalized mononuclear cell infiltrate unlike wild-type mice
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muscle
• when treated with doxycycline at 8 weeks of age
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• following neonatal induction with doxycycline
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growth/size/body
• at 12 weeks and further at 20 weeks when treated with doxycycline at 8 weeks of age
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