Phenotypes associated with this allele

• Allele Symbol: Dsht
• Allele Name: dominant short tail
• Allele ID: MGI:4437597
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dsht/Dsht^+	B6.Cg-Dsht/GrsrJ	MGI:5490561
ht2	Dsht/Dsht^+	involves: C57BL/6J * C3H/HeJ	MGI:5493516
ht3	Dsht/Dsht^+	involves: C57BL/6J * CAST/EiJ	MGI:5493515

Genotype
MGI:5490561

ht1

• Allelic Composition: Dsht/Dsht⁺
• Genetic Background: B6.Cg-Dsht/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Smaller size and short tail in Dsht/Dsht⁺ female (upper left) compared to control female sibling (lower right)

limbs/digits/tail

abnormal tail morphology ( J:196944 )

• Background Sensitivity: the short tail varies in phenotype from very short, and eighth to a quarter of an inch, and wound close to the body, or appoximately a half-inch and tightly kinked or curled only at the distal end

abnormal caudal vertebrae morphology ( J:196944 )

absent caudal vertebrae ( J:196944 )

• in some, but not all heterozygotes

decreased caudal vertebrae number ( J:196944 )

• in some, but not all, heterozygotes

abnormal tail development ( J:196944 )

short tail ( J:196944 )

curly tail ( J:196944 )

• in some, but not all, heterozygotes

kinked tail ( J:196944 )

• in some, but not all, heterozygotes

skeleton

abnormal vertebral column morphology ( J:196944 )

• thin vertebral bones

abnormal caudal vertebrae morphology ( J:196944 )

absent caudal vertebrae ( J:196944 )

• in some, but not all heterozygotes

decreased caudal vertebrae number ( J:196944 )

• in some, but not all, heterozygotes

abnormal vertebrae development ( J:196944 )

growth/size/body

decreased body weight ( J:196944 )

• slighly smaller than wildtype littermates from birth on

vision/eye

coloboma ( J:196944 )

• some, but not all, heterozygotes have corneal holes or iris colobomas, although ERGs are normal

iris coloboma ( J:196944 )

integument

belly spot ( J:196944 )

• occasional heterozygotes have a white belly spot

pigmentation

belly spot ( J:196944 )

• occasional heterozygotes have a white belly spot

Genotype
MGI:5493516

ht2

• Allelic Composition: Dsht/Dsht⁺
• Genetic Background: involves: C57BL/6J * C3H/HeJ

limbs/digits/tail

abnormal tail morphology ( J:196944 )

• Background Sensitivity: heterozygotes have a shortened, sometimes curly or kinked tail

abnormal tail development ( J:196944 )

• Background Sensitivity: when crossed to C3H/HeJ the penetrance of this dominant mutation is vastly reduced with 10% or fewer F1 offspring having the shortened, deformed tail found in much greater numbers on a mostly C57BL/6J background

short tail ( J:196944 )

kinked tail ( J:196944 )

skeleton

abnormal vertebrae development ( J:196944 )

Genotype
MGI:5493515

ht3

• Allelic Composition: Dsht/Dsht⁺
• Genetic Background: involves: C57BL/6J * CAST/EiJ

limbs/digits/tail

limbs/digits/tail phenotype ( J:196944 )

N • Background Sensitivity: The F1 or N2 outcross or backcross to CAST/EiJ from a predominantly C57BL/6J background produces no mice with abnormal tails.