Phenotypes associated with this allele

• Allele Symbol: Nr1h4^tm1.2Auw
• Allele Name: targeted mutation 1.2, Johan Auwerx
• Allele ID: MGI:4437614
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Nr1h4^tm1.2Auw/Nr1h4^tm1.2Auw	involves: 129 * C57BL/6J	MGI:4437967

Genotype
MGI:4437967

hm1

• Allelic Composition: Nr1h4^tm1.2Auw/Nr1h4^tm1.2Auw
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

increased hepatocyte apoptosis ( J:157882 )

• in non-pregnant and even more in pregnant mice

increased hepatocyte proliferation ( J:157882 )

• in pregnant mice

abnormal hepatocyte morphology ( J:157882 )

• pregnant mice do not exhibit as much of an increase in hepatocyte size as in wild-type mice

homeostasis/metabolism

increased bile salt level ( J:157882 )

• in non-pregnant mice

cellular

increased hepatocyte apoptosis ( J:157882 )

• in non-pregnant and even more in pregnant mice

increased hepatocyte proliferation ( J:157882 )

• in pregnant mice