Phenotypes associated with this allele

• Allele Symbol: Samsn1^tm1Xyw
• Allele Name: targeted mutation 1, Xiao-Yan Wen
• Allele ID: MGI:4437672
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Samsn1^tm1Xyw/Samsn1^tm1Xyw	B6.129P2-Samsn1^tm1Xyw	MGI:4437674

Genotype
MGI:4437674

hm1

• Allelic Composition: Samsn1^tm1Xyw/Samsn1^tm1Xyw
• Genetic Background: B6.129P2-Samsn1^tm1Xyw

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased B cell proliferation ( J:158032 )

• following activation with IL4 plus anti-IgM F(ab)2, LPS, or anti-CD40

increased T cell proliferation ( J:158032 )

• following NP-KLH immunization, isolated T cells exhibit a slight increase in T cell proliferation compared with similarly treated wild-type cells

increased B-1a cell number ( J:158032 )

• in the peritoneum

increased IgG3 level ( J:158032 )

• following immunization with TNP-Ficoll, mice exhibit increased anti-TNP IgG3 levels compared with similarly treated wild-type mice

increased IgM level ( J:158032 )

• following immunization with TNP-Ficoll, mice exhibit increased anti-TNP IgM levels compared with similarly treated wild-type mice

abnormal T-helper 1 physiology ( J:158032 )

• Th1-prone immune response is enhanced

abnormal T-helper 2 physiology ( J:158032 )

• Th2-prone immune response is enhanced

increased circulating interferon-gamma level ( J:158032 )

• following NP-KLH immunization, isolated lymph node T cells produce increased IFN-gamma levels compared with cells from similarly treated wild-type cells

• T cells exposed to anti-CD3 exhibit increased IFN-gamma production compared with similarly treated wild-type cells

abnormal dendritic cell physiology ( J:158032 )

• dendritic cells exhibit a slight increase in FITC-labeled dextran uptake compared with wild-type cells

• following intraperitoneal immunization with NP-KLH, dendritic cells exhibit increased FITC-labeled dextran uptake compared with wild-type cells

increased interleukin-12 secretion ( J:158032 )

• dendritic cells stimulated with anti-CD40 exhibit increased IL12 levels compared with similarly treated wild-type cells

increased interleukin-4 secretion ( J:158032 )

• following NP-KLH immunization, isolated lymph node T cells produce increased IL4 levels compared with cells from similarly treated wild-type cells

• T cells exposed to anti-CD3 exhibit increased IL4 production compared with similarly treated wild-type cells

homeostasis/metabolism

increased circulating interferon-gamma level ( J:158032 )

• following NP-KLH immunization, isolated lymph node T cells produce increased IFN-gamma levels compared with cells from similarly treated wild-type cells

• T cells exposed to anti-CD3 exhibit increased IFN-gamma production compared with similarly treated wild-type cells

hematopoietic system

increased B cell proliferation ( J:158032 )

• following activation with IL4 plus anti-IgM F(ab)2, LPS, or anti-CD40

increased T cell proliferation ( J:158032 )

• following NP-KLH immunization, isolated T cells exhibit a slight increase in T cell proliferation compared with similarly treated wild-type cells

increased B-1a cell number ( J:158032 )

• in the peritoneum

increased IgG3 level ( J:158032 )

• following immunization with TNP-Ficoll, mice exhibit increased anti-TNP IgG3 levels compared with similarly treated wild-type mice

increased IgM level ( J:158032 )

• following immunization with TNP-Ficoll, mice exhibit increased anti-TNP IgM levels compared with similarly treated wild-type mice

abnormal T-helper 1 physiology ( J:158032 )

• Th1-prone immune response is enhanced

abnormal T-helper 2 physiology ( J:158032 )

• Th2-prone immune response is enhanced

cellular

increased B cell proliferation ( J:158032 )

• following activation with IL4 plus anti-IgM F(ab)2, LPS, or anti-CD40

increased T cell proliferation ( J:158032 )

• following NP-KLH immunization, isolated T cells exhibit a slight increase in T cell proliferation compared with similarly treated wild-type cells