Analysis Tools
mortality/aging
|
• without doxycycline treatment to repress tTA, death occurs before E16.5; if treatment is continued to E14.5, animals live beyond P6
|
growth/size/body
|
• mild growth defects are observed at E15.5
|
cardiovascular system
|
• vessel branching and endothelial capillary density are increased in the dermal vasculature at E15.5
• when doxycycline is administered to pregnant females until E14.5, vessel branching and endothelial capillary density are increased in the dermal vasculature
|
|
• in retinas, tip cells and filopodia are more abundant at the angiogenic front compared to controls
|
hemorrhage
(
J:157345
)
|
• extensive hemorrhaging observed in mutants at E15.5
|
