Phenotypes associated with this allele

• Allele Symbol: Tg(Pkd1)6Mtru
• Allele Name: transgene insertion 6, Marie Trudel
• Allele ID: MGI:4437717
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Pkd1)6Mtru/0	involves: C57BL/6J * CBA/J	MGI:4437767

Genotype
MGI:4437767

tg1

• Allelic Composition: Tg(Pkd1)6Mtru/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:157952 )

• mice die around 17 months of age

renal/urinary system

increased kidney cell proliferation ( J:157952 )

• proliferation of kidney cells is increased compared to in wild-type mice

kidney cyst ( J:157952 )

• at 1 month of age, mice exhibit scattered tubular microcysts unlike wild-type mice

• at 9 months, mice develop cysts unlike wild-type mice

• by 12 to 16 months, mice exhibit severe cysts unlike wild-type mice

• mice develop cysts in the medulla, cortex and glomeruli unlike wild-type mice

• mice develop hemorrhagic cysts unlike wild-type mice

• cysts exhibit proteinaceous casts in tubular cysts and interstitial fibrosis unlike wild-type mice

• cysts originate from the proximal and collecting ducts and glomeruli unlike in wild-type mice

• cysts exhibit calcium deposits

kidney cortex cyst ( J:157952 )

• bilateral

kidney medulla cyst ( J:157952 )

decreased urine creatinine level ( J:157952 )

• at 15 months, urine creatinine content is reduced compared to in wild-type mice

increased urine osmolality ( J:157952 )

• at 15 months

increased urine protein level ( J:157952 )

• at 4 months, mice exhibit non-selective proteinuria unlike wild-type mice

decreased urine urea nitrogen level ( J:157952 )

• at 15 months, urine nitrogen content is reduced compared to in wild-type mice

hematuria ( J:157952 )

glomerulosclerosis ( J:157952 )

• partial and total

abnormal renal tubule epithelium morphology ( J:157952 )

• cystic and non-cystic tubules exhibit epithelial hyperplasia and hypertrophy with occasional polyps of varying severity unlike wild-type mice

kidney epithelium hyperplasia ( J:157952 )

• at 1 month of age

renal interstitial fibrosis ( J:157952 )

• at 7 to 16 months

dilated renal tubule ( J:157952 )

• at 1 month, mice exhibit mild tubular dilation unlike wild-type mice

• at 7 months mice develop glomerular and tubular dilation unlike wild-type mice

renal cast ( J:157952 )

• proteinaceous casts in tubular cysts

nephrocalcinosis ( J:157952 )

• calcium deposits were limited to the renal papilla

nephrolithiasis ( J:157952 )

pale kidney ( J:157952 )

polyuria ( J:157952 )

• at 15 months

cardiovascular system

thick interventricular septum ( J:157952 )

• thickness is increased

increased heart weight ( J:157952 )

cardiac hypertrophy ( J:157952 )

• mice exhibit evidence of eccentric dilated cardiac hypertrophy

heart left ventricle hypertrophy ( J:157952 )

• left ventricular wall systolic and diastolic thickness are increased compared to in wild-type mice indicating hypertrophy

abnormal aortic valve cusp morphology ( J:157952 )

• aortic valve leaflets are opaque rather than translucent as in wild-type mice

thick ventricular wall ( J:157952 )

• left ventricular wall systolic and diastolic thickness are increased compared to in wild-type mice indicating hypertrophy

dilated heart ( J:157952 )

• aortic root diameter and area are increased compared to in wild-type mice

increased cardiac muscle contractility ( J:157952 )

• mice exhibit increased fractional ejection and shortening compared with wild-type mice

liver/biliary system

increased hepatocyte proliferation ( J:157952 )

liver cyst ( J:157952 )

• in 1 in 32 mice, likely of cholangiocye origins, and affecting preferentially female mice

liver fibrosis ( J:157952 )

• mice exhibit broad band fibrosis along intrahepatic ducts unlike wild-type mice

• hepatic fibrosis is 4- to 5-fold greater than in wild-type mice

hematopoietic system

decreased hematocrit ( J:157952 )

• at 15 months

homeostasis/metabolism

decreased urine creatinine level ( J:157952 )

• at 15 months, urine creatinine content is reduced compared to in wild-type mice

increased blood osmolality ( J:157952 )

• at 15 months

increased circulating sodium level ( J:157952 )

• at 15 months

increased urine osmolality ( J:157952 )

• at 15 months

increased urine protein level ( J:157952 )

• at 4 months, mice exhibit non-selective proteinuria unlike wild-type mice

decreased urine urea nitrogen level ( J:157952 )

• at 15 months, urine nitrogen content is reduced compared to in wild-type mice

hematuria ( J:157952 )

muscle

heart left ventricle hypertrophy ( J:157952 )

• left ventricular wall systolic and diastolic thickness are increased compared to in wild-type mice indicating hypertrophy

increased cardiac muscle contractility ( J:157952 )

• mice exhibit increased fractional ejection and shortening compared with wild-type mice

cellular

increased kidney cell proliferation ( J:157952 )

• proliferation of kidney cells is increased compared to in wild-type mice

increased hepatocyte proliferation ( J:157952 )

growth/size/body

increased heart weight ( J:157952 )

cardiac hypertrophy ( J:157952 )

• mice exhibit evidence of eccentric dilated cardiac hypertrophy

heart left ventricle hypertrophy ( J:157952 )

• left ventricular wall systolic and diastolic thickness are increased compared to in wild-type mice indicating hypertrophy

kidney cyst ( J:157952 )

• at 1 month of age, mice exhibit scattered tubular microcysts unlike wild-type mice

• at 9 months, mice develop cysts unlike wild-type mice

• by 12 to 16 months, mice exhibit severe cysts unlike wild-type mice

• mice develop cysts in the medulla, cortex and glomeruli unlike wild-type mice

• mice develop hemorrhagic cysts unlike wild-type mice

• cysts exhibit proteinaceous casts in tubular cysts and interstitial fibrosis unlike wild-type mice

• cysts originate from the proximal and collecting ducts and glomeruli unlike in wild-type mice

• cysts exhibit calcium deposits

kidney cortex cyst ( J:157952 )

• bilateral

kidney medulla cyst ( J:157952 )

liver cyst ( J:157952 )

• in 1 in 32 mice, likely of cholangiocye origins, and affecting preferentially female mice