Phenotypes associated with this allele

• Allele Symbol: Tg(Pkd1)18Mtru
• Allele Name: transgene insertion 18, Marie Trudel
• Allele ID: MGI:4437719
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Pkd1)18Mtru/0	involves: C57BL/6J * CBA/J	MGI:4437768

Genotype
MGI:4437768

tg1

• Allelic Composition: Tg(Pkd1)18Mtru/0
• Genetic Background: involves: C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:157952 )

• mice die around 17 months of age

renal/urinary system

kidney cyst ( J:157952 )

• mice develop cysts in the medulla, cortex and glomeruli unlike wild-type mice

• cysts originate from the proximal and collecting ducts and glomeruli unlike in wild-type mice

• cysts exhibit calcium deposits

kidney cortex cyst ( J:157952 )

• bilateral

kidney medulla cyst ( J:157952 )

increased urine protein level ( J:157952 )

• at 4 months, mice exhibit non-selective proteinuria unlike wild-type mice

glomerulosclerosis ( J:157952 )

• partial and total

nephrocalcinosis ( J:157952 )

• calcium deposits were limited to the renal papilla

nephrolithiasis ( J:157952 )

pale kidney ( J:157952 )

cardiovascular system

cardiac fibrosis ( J:157952 )

• 35% to 40% of mice exhibit a 2- to 4-fold increase in cardiac fibrosis compared with wild-type mice

hypertension ( J:157952 )

• in some mice

hematopoietic system

decreased hematocrit ( J:157952 )

homeostasis/metabolism

increased urine protein level ( J:157952 )

• at 4 months, mice exhibit non-selective proteinuria unlike wild-type mice

growth/size/body

kidney cyst ( J:157952 )

• mice develop cysts in the medulla, cortex and glomeruli unlike wild-type mice

• cysts originate from the proximal and collecting ducts and glomeruli unlike in wild-type mice

• cysts exhibit calcium deposits

kidney cortex cyst ( J:157952 )

• bilateral

kidney medulla cyst ( J:157952 )