Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-Jag1)1Rha
• Allele Name: transgene insertion 1, Ralf H Adams
• Allele ID: MGI:4437720
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(Cdh5-tTA)D5Lbjn/0 Tg(tetO-Jag1)1Rha/0	Not Specified	MGI:4437855

Genotype
MGI:4437855

cn1

• Allelic Composition: Tg(Cdh5-tTA)D5Lbjn/0; Tg(tetO-Jag1)1Rha/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:157345 )

• without doxycycline treatment to repress tTA, death occurs before E16.5; if treatment is continued to E14.5, animals live beyond P6

growth/size/body

fetal growth retardation ( J:157345 )

• mild growth defects are observed at E15.5

cardiovascular system

abnormal vascular branching morphogenesis ( J:157345 )

• vessel branching and endothelial capillary density are increased in the dermal vasculature at E15.5

• when doxycycline is administered to pregnant females until E14.5, vessel branching and endothelial capillary density are increased in the dermal vasculature

increased angiogenesis ( J:157345 )

• in retinas, tip cells and filopodia are more abundant at the angiogenic front compared to controls

hemorrhage ( J:157345 )

• extensive hemorrhaging observed in mutants at E15.5